Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | AHR | P35869 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 4/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21295695 | 0.78 | MAPT (0.47) | MAPTKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL8964749 | 0.78 | MAPT (0.47) | MAPTKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL21295786 | 0.75 | MAPT (0.44) | MAPTKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL2089391 | 0.74 | MEN1 (0.44) | MAPTKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL16919496 | 0.73 | AHR (0.71) | MAPTKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL571563 | 0.73 | AHR (0.71) | MAPTKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL2549311 | 0.72 | MAPT (0.59) | MAPTKDM4EALDH1A1HPGDMEN1 | |
| Dibenzofuran SCHEMBL8207 | 0.72 | MAPT (0.68) | MAPTKDM4EALDH1A1HPGDMEN1 | |
| Dibenzofuran SCHEMBL9868133 | 0.72 | MAPT (0.68) | MAPTKDM4EALDH1A1HPGDMEN1 | |
| Dibenzofuran SCHEMBL29635704 | 0.72 | MAPT (0.68) | MAPTKDM4EALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. | 2005-09-08 | — | — | US | disclosed |
| EP-1320533-A4 | PRODRUGS OF A 7-ACYLAMINO-3-HETEROARYLTHIO-3-CEPHEM CARBOXYLIC ACID ANTIBIOTIC | ESSENTIAL THERAPEUTICS INC (US) | 2004-12-15 | — | — | EP | disclosed |
| US-6723716-B1 | BACTERICIDE FOR STAPHYLOCOCCUS | ESSENTIAL THERAPEUTICS, INC. | 2004-04-20 | — | — | US | disclosed |
| EP-1320533-A1 | PRODRUGS OF A 7-ACYLAMINO-3-HETEROARYLTHIO-3-CEPHEM CARBOXYLIC ACID ANTIBIOTIC | Essential Therapeutics, Inc. (US) | 2003-06-25 | — | — | EP | disclosed |
| US-20030108946-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. | 2003-06-12 | — | — | US | disclosed |
| EP-1247803-A2 | Indolinone compounds suitable for modulation of protein kinases | Sugen, Inc. (US) | 2002-10-09 | — | — | EP | disclosed |
| EP-1222194-A1 | 7-ACYLAMINO-3-HETEROARYLTHIO-3-CEPHEM CARBOXYLIC ACID ANTIBIOTICS AND PRODRUGS THEREOF | Essential Therapeutics, Inc. (US) | 2002-07-17 | — | — | EP | disclosed |
| WO-2002024708-A1 | PRODRUGS OF A 7-ACYLAMINO-3-HETEROARYLTHIO-3-CEPHEM CARBOXYLIC ACID ANTIBIOTIC | ESSENTIAL THERAPEUTICS, INC. (US) | 2002-03-28 | — | — | WO | disclosed |
| US-20020022626-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | TANG PENG CHO (US) | 2002-02-21 | — | — | US | disclosed |
| US-5698547-A | 7-(ACYLAMINO)-3-(ARYLTHIO)-3-CEPHEM-4-CARBOXYLIC ACIDS WHICH EXHIBIT ANTIBACTERIAL ACTIVITY AGAINST ORGANISMS RESISTANT TO BETA-LACTAM ANTIBIOTICS | MICROCIDE PHARMACEUTICALS, INC. (US) | 1997-12-16 | — | — | US | disclosed |
| US-5688786-A | MODIFIED CEPHALOSPORIN | MICROCIDE PHARMACEUTICALS, INC. (US) | 1997-11-18 | — | — | US | disclosed |
| WO-1997013772-A2 | CEPHALOSPORIN ANTIBIOTICS | MICROCIDE PHARMACEUTICALS, INC. (US) | 1997-04-17 | — | — | WO | disclosed |
| US-5607926-A | ACTIVE AGAINST METHICILLIN RESISTANT BACTERIA | MICROCIDE PHARMACEUTICALS, INC. (US) | 1997-03-04 | — | — | US | disclosed |
| US-5604218-A | EXHIBITS ACTIVITY AGAINST METHICILLIN RESISTANT BACTERIA | MICROCIDE PHARMACEUTICALS, INC. (US) | 1997-02-18 | — | — | US | disclosed |
| EP-0754184-A1 | CEPHALOSPORIN ANTIBIOTICS | Microcide Pharmaceuticals, Inc. (US) | 1997-01-22 | — | — | EP | disclosed |
| US-5593986-A | Cephalosporin antibiotics | MICROCIDE PHARMACEUTICALS, INC. (US) | 1997-01-14 | — | — | US | disclosed |
| WO-1996038448-A1 | β-LACTAM ANTIBIOTICS | MICROCIDE PHARMACEUTICALS, INC. (US) | 1996-12-05 | — | — | WO | disclosed |
| WO-1996038450-A1 | CEPHALOSPORIN ANTIBIOTICS | MICROCIDE PHARMACEUTICALS, INC. (US) | 1996-12-05 | — | — | WO | disclosed |
| WO-1995026966-A1 | CEPHALOSPORIN ANTIBIOTICS | MICROCIDE PHARMACEUTICALS, INC. (US) | 1995-10-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020022626-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | FRK, PTK2, DSTYK | MAPT 3115/4885KDM4E 2438/4885ALDH1A1 2206/4885 |
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | FRK, PTK2, DSTYK | MAPT 3048/4885KDM4E 2527/4885ALDH1A1 2044/4885 |
| US-20030108946-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | FRK, PTK2, DSTYK | MAPT 3115/4885KDM4E 2438/4885ALDH1A1 2206/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.