Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5375114 | 0.82 | KMT2A (0.42) | KMT2AMEN1HTTSMN1; SMN2DPP4 | |
| SCHEMBL5370680 | 0.80 | KMT2A (0.44) | KMT2AMEN1HTTSMN1; SMN2DPP4 | |
| SCHEMBL5368717 | 0.80 | KMT2A (0.40) | KMT2AMEN1HTTSMN1; SMN2DPP4 | |
| SCHEMBL5363812 | 0.75 | KMT2A (0.46) | KMT2AMEN1HTTSMN1; SMN2DPP4 | |
| SCHEMBL5378282 | 0.74 | CTSL (0.42) | — | |
| SCHEMBL5360592 | 0.71 | KMT2A (0.43) | KMT2AMEN1HTTSMN1; SMN2DPP4 | |
| SCHEMBL5371067 | 0.71 | NPC1 (0.42) | SMN1; SMN2 | |
| SCHEMBL5358539 | 0.70 | SLC6A2 (0.36) | SLC6A2SLC6A4 | |
| SCHEMBL10012549 | 0.69 | TRPV1 (0.45) | KMT2AMEN1HTTSSTR4 | |
| SCHEMBL4196853 | 0.69 | SLC6A2 (0.43) | SLC6A2SLC6A4SSTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |