Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 11/20 | 0.58 |
| ▸ | RARG | P13631 | 11/20 | 0.58 |
| ▸ | RARA | P10276 | 9/20 | 0.58 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.50 |
| ▸ | RXRA | P19793 | 9/20 | 0.48 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | GMNN | O75496 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | THPO | P40225 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5361346 | 0.90 | RARB (0.62) | RARBRARGRARACYP26A1RXRA | |
| SCHEMBL7872267 | 0.90 | RARB (0.62) | RARBRARGRARACYP26A1RXRA | |
| Hydrochloric Acid SCHEMBL5368349 | 0.86 | RARA (0.62) | RARBRARGRARACYP26A1RXRA | |
| SCHEMBL7872156 | 0.79 | CYP26A1 (0.74) | RARBRARGRARACYP26A1RXRA | |
| SCHEMBL5364757 | 0.79 | CYP26A1 (0.74) | RARBRARGRARACYP26A1RXRA | |
| SCHEMBL8521933 | 0.79 | RARB (0.59) | RARBRARGRARACYP26A1RXRA | |
| SCHEMBL1616018 | 0.74 | RARB (1.00) | RARBRARGRARACYP26A1RXRA | |
| SCHEMBL1615595 | 0.74 | RARB (1.00) | RARBRARGRARACYP26A1RXRA | |
| SCHEMBL1615597 | 0.74 | RARB (1.00) | RARBRARGRARACYP26A1RXRA | |
| SCHEMBL7872187 | 0.73 | RARB (0.57) | RARBRARGRARACYP26A1RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7259187-B2 | Tropolone derivatives | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2007-08-21 | — | — | US | disclosed |
| US-20040082550-A1 | Tropolone derivative | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2004-04-29 | — | — | US | disclosed |
| EP-1357104-A1 | TROPOLONE DERIVATIVE | Research Foundation Itsuu Laboratory (JP) | 2003-10-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082550-A1 | Tropolone derivative | NR5A2, NR0B1, MTNR1A | RARB 73/4885RARG 54/4885RARA 41/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.