Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5368614 | 0.90 | HDAC6 (0.55) | HDAC6RAB9AUSP30 | |
| SCHEMBL14425183 | 0.86 | MEN1 (0.47) | F10MEN1KMT2AHDAC6KCNH2 | |
| SCHEMBL14425189 | 0.85 | MEN1 (0.48) | F10MEN1KMT2AHDAC6KCNH2 | |
| SCHEMBL14425186 | 0.79 | HDAC6 (0.51) | F10HDAC6CACNA1IALDH1A1SMN1; SMN2 | |
| SCHEMBL5366612 | 0.78 | HDAC6 (0.52) | F10MEN1KMT2AHDAC6ALDH1A1 | |
| SCHEMBL5368330 | 0.78 | HDAC6 (0.52) | F10HDAC6KCNH2CACNA1INPC1 | |
| SCHEMBL14425184 | 0.78 | HDAC6 (0.52) | F10HDAC6CACNA1IALDH1A1SMN1; SMN2 | |
| SCHEMBL5362714 | 0.78 | HDAC6 (0.59) | HDAC6 | |
| SCHEMBL5350879 | 0.77 | GRIN2B (0.57) | MEN1KMT2AHDAC6ALDH1A1HPGD | |
| SCHEMBL5374920 | 0.76 | TPSAB1 (0.66) | F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |