Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.53 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.53 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.53 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.53 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.53 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.53 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.53 |
| ▸ | SRC | P12931 | 3/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.51 |
| ▸ | FCER2 | P06734 | 1/20 | 0.51 |
| ▸ | SYK | P43405 | 1/20 | 0.51 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.51 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 2/20 | 0.49 |
| ▸ | RAF1 | P04049 | 5/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5367143 | 0.90 | SRC (0.52) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5366300 | 0.90 | SRC (0.52) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5358785 | 0.87 | SYK (0.61) | LRRK2SRCNTRK1FCER2SYK | |
| SCHEMBL5365765 | 0.85 | SRC (0.52) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5358529 | 0.82 | MOGAT2 (0.51) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5364961 | 0.82 | MAP1LC3B (0.67) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5365553 | 0.81 | PLK4 (0.53) | SRCNTRK1FCER2SYKNTRK3 | |
| SCHEMBL7137047 | 0.81 | SRC (0.52) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7139608 | 0.81 | SRC (0.54) | LRRK2SRCNTRK1FCER2SYK | |
| SCHEMBL5360933 | 0.81 | MAP3K7 (0.58) | SRCNTRK1FCER2SYKNTRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | FRK, PTK2, DSTYK | LRRK2 289/4885PSEN1 3695/4885PSEN2 3641/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.