Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 13/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.57 |
| ▸ | ATXN2 | Q99700 | 7/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14425337 | 1.00 | ENPP2 (0.71) | ENPP2KCNH2ATXN2 | |
| SCHEMBL5359493 | 0.85 | ENPP2 (0.58) | ENPP2KCNH2ATXN2 | |
| SCHEMBL5368331 | 0.84 | ENPP2 (0.64) | ENPP2KCNH2ATXN2 | |
| SCHEMBL14425436 | 0.83 | MEN1 (0.50) | ENPP2 | |
| SCHEMBL5368740 | 0.83 | MEN1 (0.50) | ENPP2 | |
| SCHEMBL14425317 | 0.83 | MEN1 (0.50) | ENPP2 | |
| SCHEMBL14425328 | 0.82 | KDM4E (0.53) | ENPP2KCNH2 | |
| SCHEMBL14425340 | 0.82 | ENPP2 (0.48) | ENPP2ATXN2 | |
| SCHEMBL5374908 | 0.82 | ENPP2 (0.48) | ENPP2ATXN2 | |
| SCHEMBL14425339 | 0.81 | ENPP2 (0.48) | ENPP2ATXN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |