Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 12/20 | 0.64 |
| ▸ | ATXN2 | Q99700 | 5/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.58 |
| ▸ | F2 | P00734 | 1/20 | 0.55 |
| ▸ | PLG | P00747 | 1/20 | 0.55 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.55 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.55 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.55 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.55 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.55 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.55 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.52 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.52 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.52 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.52 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.52 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.52 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5359493 | 0.84 | ENPP2 (0.58) | ENPP2ATXN2KCNH2 | |
| SCHEMBL14425337 | 0.84 | ENPP2 (0.71) | ENPP2ATXN2KCNH2 | |
| SCHEMBL5369839 | 0.84 | ENPP2 (0.71) | ENPP2ATXN2KCNH2 | |
| SCHEMBL5366054 | 0.84 | TPSAB1 (0.55) | ENPP2F2PLGPRSS1PRSS2 | |
| SCHEMBL12508277 | 0.83 | ENPP2 (0.49) | ENPP2KCNH2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL12508519 | 0.82 | ENPP2 (0.54) | ENPP2KCNH2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL5362309 | 0.82 | TPSAB1 (0.57) | F2PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL17591754 | 0.81 | SMYD3 (0.69) | ENPP2ATXN2KCNH2 | |
| SCHEMBL21490197 | 0.81 | SMYD3 (0.69) | ENPP2ATXN2KCNH2 | |
| SCHEMBL17591753 | 0.81 | SMYD3 (0.69) | ENPP2ATXN2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |