Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 9/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3318318 | 0.77 | HSD11B1 (0.51) | HSD11B1KMT2ACYP3A4ALDH1A1KDM4E | |
| SCHEMBL3323248 | 0.75 | HSD11B1 (0.56) | HSD11B1KMT2ACYP3A4ALDH1A1KDM4E | |
| SCHEMBL3318119 | 0.71 | ALDH1A1 (0.52) | HSD11B1KMT2ACYP3A4ALDH1A1HPGD | |
| SCHEMBL26136684 | 0.70 | HSD11B1 (0.49) | HSD11B1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL3322001 | 0.68 | HSD11B1 (0.48) | HSD11B1KMT2ACYP3A4ALDH1A1KDM4E | |
| SCHEMBL1770092 | 0.67 | HSD11B1 (0.52) | HSD11B1KMT2AALDH1A1KDM4EMEN1 | |
| SCHEMBL3323180 | 0.67 | HSD11B1 (0.56) | HSD11B1KMT2ACYP3A4ALDH1A1KDM4E | |
| SCHEMBL3320862 | 0.67 | HSD11B1 (0.56) | HSD11B1KMT2ACYP3A4ALDH1A1KDM4E | |
| SCHEMBL5047667 | 0.66 | HSD11B1 (0.52) | HSD11B1KMT2ACYP3A4ALDH1A1KDM4E | |
| SCHEMBL15249740 | 0.66 | HSD11B1 (0.50) | HSD11B1ALDH1A1KDM4EHPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1861384-A1 | 11-BETA-HYDROXYSTEROID DEHYDROGENASE INHIBITORS | Sterix Limited (GB) | 2007-12-05 | — | — | EP | disclosed |
| WO-2006100502-A1 | 11-BETA-HYDROXYSTEROID DEHYDROGENASE INHIBITORS | STERIX LIMITED (GB) | 2006-09-28 | — | — | WO | disclosed |