Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 4/20 | 0.51 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.51 |
| ▸ | HTR3B | O95264 | 2/20 | 0.51 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.51 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.51 |
| ▸ | HTR3A | P46098 | 2/20 | 0.51 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.51 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoclidine SCHEMBL1542430 | 0.72 | GLA (0.74) | CHRNA7HTR3EHTR3BCHRNB2CHRNA4 | |
| Benzoclidine SCHEMBL1542330 | 0.72 | GLA (0.74) | CHRNA7HTR3EHTR3BCHRNB2CHRNA4 | |
| Benzoclidine SCHEMBL342347 | 0.72 | GLA (0.74) | CHRNA7HTR3EHTR3BCHRNB2CHRNA4 | |
| SCHEMBL1969701 | 0.72 | ELANE (0.49) | TSHRCYP2D6 | |
| SCHEMBL2853822 | 0.70 | CHRNA7 (0.47) | CHRNA7HTR3EHTR3BCHRNB2CHRNA4 | |
| SCHEMBL2853826 | 0.70 | CHRNA7 (0.47) | CHRNA7HTR3EHTR3BCHRNB2CHRNA4 | |
| SCHEMBL7309440 | 0.70 | CHRNA7 (0.47) | CHRNA7HTR3EHTR3BCHRNB2CHRNA4 | |
| SCHEMBL8935124 | 0.69 | CHRNA7 (0.60) | CHRNA7HTR3EHTR3BCHRNB2CHRNA4 | |
| SCHEMBL4433081 | 0.68 | KDM4E (0.50) | HTR3EHTR3BCHRNB2CHRNA4HTR3A | |
| SCHEMBL7306336 | 0.68 | CHRNA7 (0.50) | CHRNA7HTR3EHTR3BCHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828179-A2 | NICOTINIC ALPHA-7 RECEPTOR LIGANDS AND PREPARATION AND USES THEREOF | Memory Pharmaceutical Corporation (US) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006069097-A2 | NICOTINIC ALPHA-7 RECEPTOR LIGANDS AND PREPARATION AND USES THEREOF | MEMORY PHARMACEUTICALS CORPORATION (US) | 2006-06-29 | — | — | WO | disclosed |