Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.66 |
| ▸ | HPGD | P15428 | 9/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.66 |
| ▸ | RORC | P51449 | 8/20 | 0.66 |
| ▸ | GAA | P10253 | 6/20 | 0.66 |
| ▸ | GLA | P06280 | 4/20 | 0.66 |
| ▸ | NPC1 | O15118 | 9/20 | 0.66 |
| ▸ | RAB9A | P51151 | 8/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.66 |
| ▸ | MEN1 | O00255 | 6/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.66 |
| ▸ | LMNA | P02545 | 3/20 | 0.66 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.62 |
| ▸ | RELA | Q04206 | 1/20 | 0.62 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.62 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5369912 | 0.92 | ALDH1A1 (0.70) | MAPTALDH1A1HPGDKDM4ERORC | |
| SCHEMBL5368694 | 0.87 | RORC (0.67) | MAPTALDH1A1HPGDKDM4ERORC | |
| SCHEMBL5376800 | 0.85 | MAPT (0.67) | MAPTALDH1A1HPGDKDM4ERORC | |
| SCHEMBL5373408 | 0.82 | ALDH1A1 (0.57) | MAPTALDH1A1HPGDKDM4ERORC | |
| SCHEMBL5380411 | 0.82 | MAPT (0.74) | MAPTALDH1A1HPGDKDM4ERORC | |
| SCHEMBL3735493 | 0.81 | RORC (1.00) | MAPTALDH1A1HPGDKDM4ERORC | |
| SCHEMBL5382225 | 0.80 | MAPT (0.71) | MAPTALDH1A1HPGDKDM4ERORC | |
| SCHEMBL5371897 | 0.79 | ALDH1A1 (0.70) | MAPTALDH1A1HPGDKDM4ERORC | |
| SCHEMBL5921927 | 0.79 | PTPN2 (0.62) | MAPTALDH1A1HPGDKDM4EGAA | |
| SCHEMBL5390777 | 0.79 | ALDH1A1 (0.81) | MAPTALDH1A1HPGDKDM4ERORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7262318-B2 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER, INC. (US) | 2007-08-28 | — | — | US | disclosed |
| US-7262318-B2 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER, INC. (US) | 2007-08-28 | — | — | US | disclosed |
| US-7262318-B2 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER, INC. (US) | 2007-08-28 | — | — | US | disclosed |
| US-20060258723-A1 | Substituted Heteroaryl- and Phenylsulfamoyl Compounds | PFIZER INC | 2006-11-16 | — | — | US | disclosed |
| US-20050228015-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER INC | 2005-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050228015-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PPARA, PPARG, PPARD | MAPT 1786/4885ALDH1A1 2956/4885HPGD 724/4885 |
| US-20060258723-A1 | Substituted Heteroaryl- and Phenylsulfamoyl Compounds | PPARG, PPARA, PPARD | MAPT 1984/4885ALDH1A1 2752/4885HPGD 696/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.