Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | LIPA | P38571 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.34 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL975284 | 1.00 | EPHX1 (0.53) | EPHX1SMN1; SMN2SSTR4GLAKDM4E | |
| Bicarbonate SCHEMBL1125852 | 0.98 | EPHX1 (0.52) | EPHX1SMN1; SMN2SSTR4GLAKDM4E | |
| Bicarbonate SCHEMBL6036898 | 0.97 | EPHX1 (0.55) | EPHX1SMN1; SMN2SSTR4GLAKDM4E | |
| Bicarbonate SCHEMBL8827972 | 0.97 | EPHX1 (0.55) | EPHX1SMN1; SMN2SSTR4GLAKDM4E | |
| Bicarbonate SCHEMBL5597464 | 0.97 | EPHX1 (0.55) | EPHX1SMN1; SMN2SSTR4GLAKDM4E | |
| Bicarbonate SCHEMBL28367894 | 0.97 | EPHX1 (0.55) | EPHX1SMN1; SMN2SSTR4GLAKDM4E | |
| Isobutane SCHEMBL28450845 | 0.91 | EPHX1 (0.50) | EPHX1SMN1; SMN2SSTR4GLAKDM4E | |
| Acetic Acid SCHEMBL4353702 | 0.90 | EPHX1 (0.53) | EPHX1SMN1; SMN2SSTR4GLAKDM4E | |
| Bicarbonate SCHEMBL28626633 | 0.89 | EPHX1 (0.48) | EPHX1SMN1; SMN2SSTR4GLAKDM4E | |
| SCHEMBL23174694 | 0.84 | EPHX1 (0.48) | EPHX1SMN1; SMN2SSTR4GLAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220212420-A1 | MULTI-COMPOUND FIBER REINFORCED COMPOSITES AND METHODS OF MAKING THE SAME USING FRONTAL POLYMERIZATION AND TARGETED PHOTOSENSITIZER ADDITIVES | GM Global Technology Operations LLC (US) | 2022-07-07 | — | — | US | claimed |
| US-20220212420-A1 | MULTI-COMPOUND FIBER REINFORCED COMPOSITES AND METHODS OF MAKING THE SAME USING FRONTAL POLYMERIZATION AND TARGETED PHOTOSENSITIZER ADDITIVES | GM Global Technology Operations LLC (US) | 2022-07-07 | — | — | US | disclosed |
| US-10738146-B2 | Process for frontal polymerization of cationically polymerizable monomers | TECHNISCHE UNIVERSITAET WIEN (AT) | 2020-08-11 | — | — | US | disclosed |
| US-20190309123-A1 | PROCESS FOR FRONTAL POLYMERIZATION OF CATIONICALLY POLYMERIZABLE MONOMERS | TECHNISCHE UNIVERSITAET WIEN (AT) | 2019-10-10 | — | — | US | disclosed |
| CN-104870542-A | Composite particles including a fluoropolymer, methods of making, and articles including the same | 3M INNOVATIVE PROPERTIES CO | 2015-08-26 | — | — | CN | disclosed |
| CN-101778918-B | Pressure sensitive adhesive composition with improved initial tack | 3M INNOVATIVE PROPERTIES CO | 2013-03-27 | — | — | CN | disclosed |
| CN-101778918-A | Pressure sensitive adhesive composition with improved initial tack | 3M INNOVATIVE PROPERTIES CO | 2010-07-14 | — | — | CN | disclosed |
| CN-101688090-A | Colored acrylic resin adhesive and marking film | 3M INNOVATIVE PROPERTIES CO | 2010-03-31 | — | — | CN | disclosed |
| CN-100354346-C | Microspheres | AKZO NOBEL NV (NL) | 2007-12-12 | — | — | CN | disclosed |
| US-7157526-B2 | Aqueous primary dispersion, substantially or completely devoid of volatile organic substances, method for the production thereof and use of the same | BASF COATINGS AG (DE) | 2007-01-02 | — | — | US | disclosed |
| CN-1738853-A | Microspheres | AKZO NOBEL NV (NL) | 2006-02-22 | — | — | CN | disclosed |
| US-20040048968-A1 | Aqueous primary dispersion, substantially or completely devoid of volatile organic substances, method for the production thereof and use of the same | BASF COATINGS AKTIENGESELLSCHAFT (DE) | 2004-03-11 | — | — | US | disclosed |
| CN-1006711-B | CURABLE COMPOSITION METHOD FOR MANUFACTURE THEREOF AND USES THEREOF | NIPPON SHOKUPAI KAGAKU KOGYO C (JP) | 1990-02-07 | — | — | CN | disclosed |
| CN-86105386-A | Curable compositions and manufacture method thereof and application | — | 1987-04-08 | — | — | CN | disclosed |
| CN-86104545-A | Produce curable fluorinated elastomer and relevant resulting method for product | — | 1987-02-04 | — | — | CN | disclosed |