Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 5/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | LIPA | P38571 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL28367894 | 1.00 | EPHX1 (0.55) | EPHX1SMN1; SMN2SSTR4GLAKDM4E | |
| Bicarbonate SCHEMBL6036898 | 1.00 | EPHX1 (0.55) | EPHX1SMN1; SMN2SSTR4GLAKDM4E | |
| Bicarbonate SCHEMBL8827972 | 1.00 | EPHX1 (0.55) | EPHX1SMN1; SMN2SSTR4GLAKDM4E | |
| Bicarbonate SCHEMBL975284 | 0.97 | EPHX1 (0.53) | EPHX1SMN1; SMN2SSTR4GLAKDM4E | |
| Bicarbonate SCHEMBL5372441 | 0.97 | EPHX1 (0.53) | EPHX1SMN1; SMN2SSTR4GLAKDM4E | |
| Bicarbonate SCHEMBL1125852 | 0.95 | EPHX1 (0.52) | EPHX1SMN1; SMN2SSTR4GLAKDM4E | |
| Isobutane SCHEMBL28450845 | 0.93 | EPHX1 (0.50) | EPHX1SMN1; SMN2SSTR4GLAKDM4E | |
| Acetic Acid SCHEMBL4353702 | 0.92 | EPHX1 (0.53) | EPHX1SMN1; SMN2SSTR4GLAKDM4E | |
| Bicarbonate SCHEMBL28626633 | 0.91 | EPHX1 (0.48) | EPHX1SMN1; SMN2SSTR4GLAKDM4E | |
| SCHEMBL23174694 | 0.86 | EPHX1 (0.48) | EPHX1SMN1; SMN2SSTR4GLAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230272137-A1 | CROSSLINKABLE FLUOROPOLYMER AND COATING FORMED THEREFROM | THE CHEMOURS COMPANY FC, LLC (US) | 2023-08-31 | — | — | US | disclosed |
| US-11674047-B2 | Composition for manufacturing passivation layer and passivation layer using the same | THE CHEMOURS COMPANY FC, LLC (US) | 2023-06-13 | — | — | US | disclosed |
| EP-4178994-A1 | CROSSLINKABLE FLUOROPOLYMER AND COATING FORMED THEREFROM | The Chemours Company FC, LLC (US) | 2023-05-17 | — | — | EP | disclosed |
| CN-115161913-A | Method for sizing fibers, coated fibers and fiber-reinforced composites | 清华大学 | 2022-10-11 | — | — | CN | disclosed |
| EP-3411445-B1 | FLUOROPOLYMER SOLUTION FOR FORMING A FLUOROPOLYMER COATING | CHEMOURS CO FC LLC (US) | 2022-07-13 | — | — | EP | disclosed |
| WO-2022011203-A1 | CROSSLINKABLE FLUOROPOLYMER AND COATING FORMED THEREFROM | THE CHEMOURS COMPANY FC, LLC (US) | 2022-01-13 | — | — | WO | disclosed |
| EP-3918015-A1 | COMPOSITION FOR MANUFACTURING PASSIVATION LAYER AND PASSIVATION LAYER USING THE SAME | The Chemours Company FC, LLC (US) | 2021-12-08 | — | — | EP | disclosed |
| WO-2020159974-A1 | COMPOSITION FOR MANUFACTURING PASSIVATION LAYER AND PASSIVATION LAYER USING THE SAME | THE CHEMOURS COMPANY FC, LLC (US) | 2020-08-06 | — | — | WO | disclosed |
| US-20200239724-A1 | COMPOSITION FOR MANUFACTURING PASSIVATION LAYER AND PASSIVATION LAYER USING THE SAME | JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT | 2020-07-30 | — | — | US | disclosed |
| US-20200165480-A1 | PHOTOCROSSLINKABLE FLUOROPOLYMER COATING COMPOSITION AND COATING LAYER FORMED THEREFROM | THE CHEMOURS COMPANY FC, LLC (US) | 2020-05-28 | — | — | US | disclosed |
| EP-0629633-A2 | Dinucleotide analogues, intermediates therefor and oligonucleotides derived therefrom | CIBA-GEIGY AG (CH) | 1994-12-21 | — | — | EP | disclosed |
| EP-0614906-A1 | Mononucleotide analogues and intermediates therefor | CIBA-GEIGY AG (CH) | 1994-09-14 | — | — | EP | disclosed |
| EP-0614907-A1 | Dinucleotide and oligonucleotide analogues | CIBA-GEIGY AG (CH) | 1994-09-14 | — | — | EP | disclosed |
| EP-0614900-A1 | Phosphinate esters | CIBA-GEIGY AG (CH) | 1994-09-14 | — | — | EP | disclosed |
| EP-0067124-B1 | PRODUCTION OF 5,5-DISUBSTITUTED 3-OXO-PENT-4-ENOIC ACIDS, THEIR HALIDES, ESTERS, THIOESTERS AND AMIDES; AND THEIR USE IN ANTIFUNGAL AND ANTIBACTERIAL COMPOSITIONS | CIBA-GEIGY AG (CH) | 1985-05-02 | — | — | EP | disclosed |
| US-4472589-A | 4-Chloro-4-chloromethyloxetan-2-one | CIBA-GEIGY CORPORATION (US) | 1984-09-18 | — | — | US | disclosed |
| US-4398033-A | 4-Chloro-4-chloromethyloxetan-2-one and a process for its production | CIBA-GEIGY CORPORATION (US) | 1983-08-09 | — | — | US | disclosed |
| US-4384966-A | FRICTION AND WEAR RESISTANCE ADDITIVES FOR LUBRICANTS, FIREPROOFING POLYMERS | CIBA-GEIGY CORPORATION (US) | 1983-05-24 | — | — | US | disclosed |
| EP-0067124-A1 | Production of 5,5-disubstituted 3-oxo-pent-4-enoic acids, their halides, esters, thioesters and amides; and their use in antifungal and antibacterial compositions | CIBA-GEIGY AG (CH) | 1982-12-15 | — | — | EP | disclosed |
| US-4363923-A | ALGISTATS BACTERICIDES, FUNGICIDES | CIBA-GEIGY CORPORATION (US) | 1982-12-14 | — | — | US | disclosed |