SCHEMBL5373797

SCHEMBL5373797

CCOC(=O)CCc1cn(Cc2ccc(OCc3csc(-c4ccccc4)n3)cc2)nc1-c1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.47
HDAC1 Q13547 1/20 0.42
HDAC7 Q8WUI4 1/20 0.42
RAB9A P51151 5/20 0.41
MAPT P10636 2/20 0.41
SMN1; SMN2 Q16637 3/20 0.41
NPC1 O15118 3/20 0.41
TP53 P04637 3/20 0.41
NFKB1 P19838 2/20 0.41
NFKB2 Q00653 2/20 0.41
RELA Q04206 2/20 0.41
TSHR P16473 2/20 0.41
PKM P14618 1/20 0.41
HSD17B10 Q99714 1/20 0.41
CYSLTR2 Q9NS75 1/20 0.41
CYSLTR1 Q9Y271 1/20 0.41
KLKB1 P03952 1/20 0.40
KLK1 P06870 1/20 0.40
PPARA Q07869 1/20 0.39
POLB P06746 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6156589 0.91 ALDH1A1 (0.49) ALDH1A1RAB9AMAPTSMN1; SMN2NPC1
SCHEMBL5381554 0.90 HDAC1 (0.46) ALDH1A1HDAC1HDAC7RAB9AMAPT
SCHEMBL5387884 0.90 KLKB1 (0.41) ALDH1A1HDAC1HDAC7RAB9AMAPT
SCHEMBL5376358 0.86 ALDH1A1 (0.40) ALDH1A1HDAC1HDAC7RAB9AMAPT
SCHEMBL5374912 0.85 HDAC1 (0.44) ALDH1A1HDAC1HDAC7MAPTSMN1; SMN2
SCHEMBL5377258 0.84 ALDH1A1 (0.48) ALDH1A1RAB9AMAPTSMN1; SMN2NPC1
Sipoglitazar SCHEMBL5380746 0.83 ALDH1A1 (0.47) ALDH1A1RAB9AMAPTSMN1; SMN2NPC1
SCHEMBL5383041 0.83 HDAC1 (0.53) ALDH1A1HDAC1HDAC7RAB9AMAPT
SCHEMBL5383106 0.82 FFAR1 (0.47) ALDH1A1HDAC1HDAC7RAB9AMAPT
SCHEMBL5374845 0.82 HDAC1 (0.47) ALDH1A1HDAC1HDAC7MAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7179823-B1 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-02-20 US disclosed
EP-1457490-A1 5-membered N-heterocyclic compounds with hypoglycemic and hypolipidemic activity Takeda Chemical Industries, Ltd. (JP) 2004-09-15 EP disclosed
EP-1228067-B1 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2004-07-14 EP disclosed
EP-1228067-A1 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGYLCEMIC AND HYPOLIPIDEMIC ACTIVITY Takeda Chemical Industries, Ltd. (JP) 2002-08-07 EP disclosed
WO-2001038325-A1 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-05-31 WO disclosed