Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 6/20 | 0.42 |
| ▸ | TP53 | P04637 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.42 |
| ▸ | RELA | Q04206 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.40 |
| ▸ | KLK1 | P06870 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sipoglitazar SCHEMBL5380746 | 0.93 | ALDH1A1 (0.47) | ALDH1A1RAB9ATP53SMN1; SMN2NPC1 | |
| SCHEMBL5373797 | 0.91 | ALDH1A1 (0.47) | ALDH1A1RAB9ATP53SMN1; SMN2NPC1 | |
| SCHEMBL5382686 | 0.90 | ALDH1A1 (0.41) | ALDH1A1RAB9ATP53SMN1; SMN2NPC1 | |
| SCHEMBL5392101 | 0.86 | CYSLTR2 (0.41) | ALDH1A1KLKB1PPARACYSLTR2CYSLTR1 | |
| SCHEMBL5374629 | 0.85 | PPARG (0.46) | ALDH1A1PPARAL3MBTL1PPARGPPARD | |
| SCHEMBL5381015 | 0.85 | ALOX5AP (0.42) | PPARACYSLTR2CYSLTR1PPARGPPARD | |
| SCHEMBL5387654 | 0.85 | FFAR1 (0.54) | ALDH1A1TP53HSD17B10MAPTKDM4E | |
| SCHEMBL5377258 | 0.84 | ALDH1A1 (0.48) | ALDH1A1RAB9ATP53SMN1; SMN2NPC1 | |
| SCHEMBL5387466 | 0.83 | MAPT (0.44) | RAB9ATP53SMN1; SMN2MAPTKDM4E | |
| SCHEMBL5387742 | 0.83 | L3MBTL1 (0.46) | ALDH1A1PPARAL3MBTL1PPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050014813-A1 | Process for production of pyrazole compounds | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-01-20 | — | — | US | disclosed |
| EP-1445254-A1 | PROCESS FOR PRODUCTION OF PYRAZOLE COMPOUNDS | Takeda Chemical Industries, Ltd. (JP) | 2004-08-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014813-A1 | Process for production of pyrazole compounds | REN, CYP11B1, CYP11B2 | ALDH1A1 1132/4885RAB9A 2309/4885TP53 717/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.