Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 16/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 10/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5378986 | 0.96 | FFAR1 (0.47) | FFAR1FFAR4AKR1B1MAPTRAB9A | |
| SCHEMBL5377468 | 0.93 | TP53 (0.44) | FFAR1FFAR4MAPTPPARAALDH1A1 | |
| SCHEMBL5385312 | 0.91 | FFAR1 (0.47) | FFAR1FFAR4AKR1B1NPC1MAPT | |
| SCHEMBL5380518 | 0.91 | FFAR1 (0.47) | FFAR1FFAR4AKR1B1 | |
| SCHEMBL5385880 | 0.90 | ALDH1A1 (0.46) | FFAR1FFAR4NPC1MAPTTSHR | |
| SCHEMBL5387592 | 0.90 | FFAR1 (0.41) | FFAR1FFAR4AKR1B1 | |
| SCHEMBL5377477 | 0.89 | PPARA (0.46) | FFAR1FFAR4AKR1B1NPC1MAPT | |
| SCHEMBL5377160 | 0.88 | FFAR1 (0.46) | FFAR1FFAR4AKR1B1L3MBTL1 | |
| SCHEMBL5379417 | 0.88 | FFAR1 (0.44) | FFAR1FFAR4AKR1B1MAPT | |
| SCHEMBL5377258 | 0.86 | ALDH1A1 (0.48) | FFAR1FFAR4NPC1MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7179823-B1 | 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-20 | — | — | US | disclosed |
| EP-1457490-A1 | 5-membered N-heterocyclic compounds with hypoglycemic and hypolipidemic activity | Takeda Chemical Industries, Ltd. (JP) | 2004-09-15 | — | — | EP | disclosed |
| EP-1228067-B1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-07-14 | — | — | EP | disclosed |
| EP-1228067-A1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGYLCEMIC AND HYPOLIPIDEMIC ACTIVITY | Takeda Chemical Industries, Ltd. (JP) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001038325-A1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-31 | — | — | WO | disclosed |