Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 15/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 10/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5374467 | 0.96 | FFAR1 (0.45) | FFAR1FFAR4AKR1B1PPARAALDH1A1 | |
| SCHEMBL5377468 | 0.93 | TP53 (0.44) | FFAR1FFAR4PPARAALDH1A1MAPT | |
| SCHEMBL5380518 | 0.92 | FFAR1 (0.47) | FFAR1FFAR4AKR1B1 | |
| SCHEMBL5385312 | 0.92 | FFAR1 (0.47) | FFAR1FFAR4AKR1B1PPARAALDH1A1 | |
| SCHEMBL5377477 | 0.92 | PPARA (0.46) | FFAR1FFAR4AKR1B1PPARAALDH1A1 | |
| SCHEMBL5377160 | 0.91 | FFAR1 (0.46) | FFAR1FFAR4AKR1B1 | |
| SCHEMBL5379417 | 0.91 | FFAR1 (0.44) | FFAR1FFAR4AKR1B1MAPT | |
| SCHEMBL5387592 | 0.90 | FFAR1 (0.41) | FFAR1FFAR4AKR1B1 | |
| SCHEMBL5377258 | 0.90 | ALDH1A1 (0.48) | FFAR1FFAR4PPARAALDH1A1MAPT | |
| SCHEMBL5377142 | 0.88 | PPARA (0.45) | FFAR1FFAR4PPARAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7179823-B1 | 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-20 | — | — | US | disclosed |
| EP-1457490-A1 | 5-membered N-heterocyclic compounds with hypoglycemic and hypolipidemic activity | Takeda Chemical Industries, Ltd. (JP) | 2004-09-15 | — | — | EP | disclosed |
| EP-1228067-B1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-07-14 | — | — | EP | disclosed |