Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 2/20 | 0.35 |
| ▸ | GABRD | O14764 | 2/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.35 |
| ▸ | GABRE | P78334 | 2/20 | 0.35 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.35 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.35 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL28942687 | 1.00 | LMNA (0.71) | LMNATHRBALDH1A1FFAR3HSD17B10 | |
| Bicarbonate SCHEMBL28895866 | 1.00 | LMNA (0.71) | LMNATHRBALDH1A1FFAR3HSD17B10 | |
| Bicarbonate SCHEMBL9453328 | 0.97 | LMNA (0.67) | LMNATHRBALDH1A1FFAR3HSD17B10 | |
| Acetic Acid SCHEMBL23907968 | 0.92 | LMNA (0.67) | LMNATHRBALDH1A1FFAR3HSD17B10 | |
| Acetic Acid SCHEMBL222953 | 0.92 | LMNA (0.67) | LMNATHRBALDH1A1FFAR3HSD17B10 | |
| Propionic Acid SCHEMBL8820914 | 0.89 | LMNA (0.63) | LMNATHRBALDH1A1FFAR3HSD17B10 | |
| Acetic Acid SCHEMBL8529879 | 0.89 | LMNA (0.63) | LMNATHRBALDH1A1FFAR3HSD17B10 | |
| Carbamic Acid SCHEMBL5387548 | 0.89 | LMNA (0.63) | LMNATHRBALDH1A1GABRPGABRD | |
| Acetone SCHEMBL590699 | 0.88 | LMNA (0.71) | LMNATHRBALDH1A1HSD17B10ALOX15 | |
| Pyruvate SCHEMBL1893245 | 0.87 | LMNA (0.60) | LMNATHRBALDH1A1FFAR3HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007169414-A | POLYACETAL CARBONATE BLOCK COPOLYMER AND ITS MANUFACTURING METHOD | POLYPLASTICS CO | 2007-07-05 | — | — | JP | disclosed |
| CN-1300812-A | Cleaning composition | PROCTER & GAMBLE (US) | 2001-06-27 | — | — | CN | disclosed |
| US-5575944-A | Acetal-containing working fluid composition for refrigerating machine | KAO CORPORATION (JP) | 1996-11-19 | — | — | US | disclosed |
| US-4946759-A | CLEAVAGE PRODUCT UNDER THE ACTION OF ACTINIC RADIATION | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-08-07 | — | — | US | disclosed |