Acetic Acid — predicted protein targets

Known targets — ChEMBL curated mechanism

ADRA2A ADRA2B ADRA2C ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CALCR CHRNA3 CHRNB4 ESR1 ESR2 GHSR GNRHR GSC1 HSPA8 MALT1 MC1R MC4R NOS1 NOS2 NOS3 OPRK1 OXTR RAMP1 RAMP2 RAMP3 SCN5A SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 dacA dacB dacC folP ftsI mrcA mrcB mrdA rplA rplB rplC rplD rplE rplF rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmF rpmG rpmH rpmI rpmJ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	LMNA	P02545	2/20	0.67

▸	ALDH1A1	P00352	5/20	0.39

▸	HSD17B10	Q99714	1/20	0.39

▸	FFAR3	O14843	2/20	0.39

▸	LCK	P06239	1/20	0.39

▸	FYN	P06241	1/20	0.39

▸	THRB	P10828	1/20	0.38

▸	TDP1	Q9NUW8	2/20	0.33

▸	GABRP	O00591	2/20	0.33

▸	GABRD	O14764	2/20	0.33

▸	GABRA1	P14867	2/20	0.33

▸	GABRB1	P18505	2/20	0.33

▸	GABRG2	P18507	2/20	0.33

▸	GABRB3	P28472	2/20	0.33

▸	GABRA5	P31644	2/20	0.33

▸	GABRA3	P34903	2/20	0.33

▸	GABRA2	P47869	2/20	0.33

▸	GABRB2	P47870	2/20	0.33

▸	GABRA4	P48169	2/20	0.33

▸	GABRE	P78334	2/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Acetic Acid SCHEMBL222953	1.00	LMNA (0.67)	LMNAALDH1A1HSD17B10FFAR3LCK
Acetic Acid SCHEMBL8529879	0.97	LMNA (0.63)	LMNAALDH1A1HSD17B10FFAR3LCK
Acetic Acid SCHEMBL7064477	0.95	LMNA (0.60)	LMNAALDH1A1HSD17B10FFAR3LCK
Acetic Acid SCHEMBL4211515	0.93	LMNA (0.57)	LMNAALDH1A1HSD17B10FFAR3LCK
Bicarbonate SCHEMBL5374586	0.92	LMNA (0.71)	LMNAALDH1A1HSD17B10FFAR3THRB
Bicarbonate SCHEMBL28895866	0.92	LMNA (0.71)	LMNAALDH1A1HSD17B10FFAR3THRB
Acetone SCHEMBL590699	0.92	LMNA (0.71)	LMNAALDH1A1HSD17B10THRBTDP1
Bicarbonate SCHEMBL28942687	0.92	LMNA (0.71)	LMNAALDH1A1HSD17B10FFAR3THRB
Pyruvate SCHEMBL1893245	0.90	LMNA (0.60)	LMNAALDH1A1HSD17B10FFAR3THRB
Butanedione SCHEMBL4368674	0.89	LMNA (0.67)	LMNAALDH1A1HSD17B10THRBTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-20210317058-A1	DEGRADABLE POLYMERS AND MONOMERS THEREFOR	THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS	2021-10-14	—	—	US	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20210317058-A1	DEGRADABLE POLYMERS AND MONOMERS THEREFOR	HDHD5, LTA4H, KYNU	LMNA 443/4885ALDH1A1 168/4885HSD17B10 793/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.