Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 7/20 | 0.57 |
| ▸ | HTR2C | P28335 | 7/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.39 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5374623 | 1.00 | HTR2A (0.57) | HTR2AHTR2CALDH1A1PTGDRPTGDR2 | |
| SCHEMBL5374632 | 1.00 | HTR2A (0.57) | HTR2AHTR2CALDH1A1PTGDRPTGDR2 | |
| Hydrochloric Acid SCHEMBL5371053 | 0.99 | HTR2A (0.56) | HTR2AHTR2CALDH1A1PTGDRPTGDR2 | |
| Hydrochloric Acid SCHEMBL5371045 | 0.99 | HTR2A (0.56) | HTR2AHTR2CALDH1A1PTGDRPTGDR2 | |
| Hydrochloric Acid SCHEMBL5371047 | 0.99 | HTR2A (0.56) | HTR2AHTR2CALDH1A1PTGDRPTGDR2 | |
| SCHEMBL5372172 | 0.91 | HTR2A (0.56) | HTR2AHTR2CALDH1A1PTGDRPTGDR2 | |
| SCHEMBL5372183 | 0.91 | HTR2A (0.56) | HTR2AHTR2CALDH1A1PTGDRPTGDR2 | |
| SCHEMBL5372175 | 0.91 | HTR2A (0.56) | HTR2AHTR2CALDH1A1PTGDRPTGDR2 | |
| Hydrochloric Acid SCHEMBL5372605 | 0.90 | HTR2A (0.55) | HTR2AHTR2CALDH1A1PTGDRPTGDR2 | |
| Hydrochloric Acid SCHEMBL5372602 | 0.90 | HTR2A (0.55) | HTR2AHTR2CALDH1A1PTGDRPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7276607-B2 | 5-HT7 receptor antagonists | MERCK SHARP & DOHME LIMITED (GB) | 2007-10-02 | — | — | US | claimed |
| US-20050080077-A1 | 5-ht7 receptor antagonists | MERCK SHARP & DOHME LTD. (GB) | 2005-04-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050080077-A1 | 5-ht7 receptor antagonists | HTR7, HTR2B, HTR1A | HTR2A 13/4885HTR2C 4/4885ALDH1A1 2892/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.