Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.60 |
| ▸ | HPGD | P15428 | 7/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 11/20 | 0.59 |
| ▸ | LMNA | P02545 | 11/20 | 0.59 |
| ▸ | HTT | P42858 | 7/20 | 0.59 |
| ▸ | PKM | P14618 | 2/20 | 0.59 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 7/20 | 0.57 |
| ▸ | GAA | P10253 | 5/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.57 |
| ▸ | GLA | P06280 | 4/20 | 0.57 |
| ▸ | RORC | P51449 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.54 |
| ▸ | RELA | Q04206 | 2/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5373408 | 0.91 | ALDH1A1 (0.57) | ALDH1A1HPGDSMN1; SMN2LMNAHTT | |
| SCHEMBL5375367 | 0.90 | ALDH1A1 (0.60) | ALDH1A1HPGDSMN1; SMN2LMNAHTT | |
| SCHEMBL5380411 | 0.89 | MAPT (0.74) | ALDH1A1HPGDSMN1; SMN2LMNAHTT | |
| SCHEMBL5369912 | 0.81 | ALDH1A1 (0.70) | ALDH1A1HPGDSMN1; SMN2LMNAHTT | |
| SCHEMBL5382225 | 0.80 | MAPT (0.71) | ALDH1A1HPGDSMN1; SMN2LMNAHTT | |
| SCHEMBL5371897 | 0.79 | ALDH1A1 (0.70) | ALDH1A1HPGDSMN1; SMN2LMNAHTT | |
| SCHEMBL5377046 | 0.79 | PTPN5 (0.61) | ALDH1A1HPGDLMNAHTTMAPT | |
| SCHEMBL5376843 | 0.78 | ALDH1A1 (0.70) | ALDH1A1HPGDSMN1; SMN2LMNAHTT | |
| SCHEMBL5373585 | 0.78 | ALDH1A1 (0.56) | ALDH1A1HPGDSMN1; SMN2LMNAHTT | |
| SCHEMBL5373258 | 0.78 | ALDH1A1 (0.55) | ALDH1A1HPGDSMN1; SMN2LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7262318-B2 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER, INC. (US) | 2007-08-28 | — | — | US | disclosed |
| US-7262318-B2 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER, INC. (US) | 2007-08-28 | — | — | US | disclosed |
| US-7262318-B2 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER, INC. (US) | 2007-08-28 | — | — | US | disclosed |
| US-20060258723-A1 | Substituted Heteroaryl- and Phenylsulfamoyl Compounds | PFIZER INC | 2006-11-16 | — | — | US | disclosed |
| US-20050228015-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER INC | 2005-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050228015-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PPARA, PPARG, PPARD | ALDH1A1 2956/4885HPGD 724/4885SMN1; SMN2 3404/4885 |
| US-20060258723-A1 | Substituted Heteroaryl- and Phenylsulfamoyl Compounds | PPARG, PPARA, PPARD | ALDH1A1 2752/4885HPGD 696/4885SMN1; SMN2 3296/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.