Sugi Predict

Sugi Predict / Compounds / SCHEMBL5375367

SCHEMBL5375367

SCHEMBL5375367

Cc1ccc(S(=O)(=O)Nc2ccc(-c3nc4ccccc4s3)cc2)cc1C(=O)O

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 11/20 0.60
▸ HPGD P15428 11/20 0.60
▸ TP53 P04637 2/20 0.57
▸ MAPT P10636 10/20 0.57
▸ KDM4E B2RXH2 9/20 0.57
▸ GAA P10253 5/20 0.57
▸ GLA P06280 4/20 0.57
▸ RORC P51449 3/20 0.57
▸ MEN1 O00255 9/20 0.57
▸ KMT2A Q03164 9/20 0.57
▸ SMN1; SMN2 Q16637 8/20 0.57
▸ NPC1 O15118 7/20 0.57
▸ RAB9A P51151 7/20 0.57
▸ LMNA P02545 3/20 0.57
▸ RUNX1 Q01196 1/20 0.55
▸ CBFB Q13951 1/20 0.55
▸ POLB P06746 1/20 0.54
▸ NFKB1 P19838 2/20 0.54
▸ HTT P42858 2/20 0.54
▸ NFKB2 Q00653 2/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5375174 0.90 ALDH1A1 (0.60) ALDH1A1HPGDMAPTKDM4EGAA
SCHEMBL5380411 0.89 MAPT (0.74) ALDH1A1HPGDTP53MAPTKDM4E
SCHEMBL5373585 0.88 ALDH1A1 (0.56) ALDH1A1HPGDTP53MAPTKDM4E
SCHEMBL5373258 0.88 ALDH1A1 (0.55) ALDH1A1HPGDTP53MAPTKDM4E
SCHEMBL3679894 0.82 ALDH1A1 (0.78) ALDH1A1HPGDTP53MAPTKDM4E
SCHEMBL5380301 0.82 POLB (0.56) ALDH1A1GAAMEN1KMT2ASMN1; SMN2
SCHEMBL5373408 0.82 ALDH1A1 (0.57) ALDH1A1HPGDTP53MAPTKDM4E
SCHEMBL5369912 0.81 ALDH1A1 (0.70) ALDH1A1HPGDTP53MAPTKDM4E
SCHEMBL31000045 0.80 TP53 (0.63) ALDH1A1HPGDTP53MAPTKDM4E
SCHEMBL5382225 0.80 MAPT (0.71) ALDH1A1HPGDTP53MAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7262318-B2 Substituted heteroaryl- and phenylsulfamoyl compounds PFIZER, INC. (US) 2007-08-28 — — US disclosed
US-7262318-B2 Substituted heteroaryl- and phenylsulfamoyl compounds PFIZER, INC. (US) 2007-08-28 — — US disclosed
US-7262318-B2 Substituted heteroaryl- and phenylsulfamoyl compounds PFIZER, INC. (US) 2007-08-28 — — US disclosed
EP-1725524-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS Pfizer Products Incorporated (US) 2006-11-29 — — EP disclosed
US-20060258723-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds PFIZER INC 2006-11-16 — — US disclosed
US-20050228015-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PFIZER INC 2005-10-13 — — US disclosed
WO-2005092845-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER PRODUCTS INC. (US) 2005-10-06 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050228015-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PPARA, PPARG, PPARD ALDH1A1 2956/4885HPGD 724/4885TP53 3421/4885
US-20060258723-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds PPARG, PPARA, PPARD ALDH1A1 2752/4885HPGD 696/4885TP53 3528/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.