Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 13/20 | 0.40 |
| ▸ | HTR1A | P08908 | 12/20 | 0.40 |
| ▸ | HTR2A | P28223 | 12/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.40 |
| ▸ | DRD3 | P35462 | 5/20 | 0.38 |
| ▸ | HTR2C | P28335 | 4/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.38 |
| ▸ | HRH1 | P35367 | 4/20 | 0.38 |
| ▸ | HTR6 | P50406 | 4/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.38 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5361320 | 0.97 | CYP1A2 (0.42) | CYP1A2CYP2D6CYP2C9CYP2C19ADRA1D | |
| SCHEMBL5369068 | 0.90 | DRD2 (0.43) | DRD2HTR1AHTR2AHRH3DRD3 | |
| SCHEMBL5374861 | 0.86 | DRD4 (0.49) | ADRA1DDRD2HTR1AHTR2ADRD3 | |
| SCHEMBL5367332 | 0.85 | DRD2 (0.40) | DRD2HTR1AHTR2AHRH3DRD3 | |
| SCHEMBL1381393 | 0.84 | NPC1 (0.47) | HTR2AKCNH2 | |
| SCHEMBL1381396 | 0.84 | NPC1 (0.47) | HTR2AKCNH2 | |
| SCHEMBL5367700 | 0.83 | DRD4 (0.45) | DRD2HTR1AHTR2AHRH3KCNH2 | |
| SCHEMBL5368310 | 0.83 | LMNA (0.40) | CYP1A2CYP2D6CYP2C19ADRA1DDRD2 | |
| Hydrochloric Acid SCHEMBL5362477 | 0.82 | BCHE (0.45) | DRD2HTR1AHTR2AHRH3KCNH2 | |
| SCHEMBL5361305 | 0.80 | MCHR1 (0.38) | ADRA1DDRD2HTR1AHTR2AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7253165-B2 | Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists | AVENTIS PHARMACEUTICALS INC. (US) | 2007-08-07 | — | — | US | claimed |
| US-20050107377-A1 | Benzisoxazolyl-,pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists | AVENTIS PHARMACEUTIALS INC. (US) | 2005-05-19 | — | — | US | claimed |
| EP-1216244-B1 | Benzisoxazolyl-, pyridoisoxazolyl- and benzthienyl-phenoxy derivatives useful as D4 antagonists | AVENTIS PHARMA INC (US) | 2003-08-13 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107377-A1 | Benzisoxazolyl-,pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists | DRD4, DRD2, DRD1 | CYP1A2 283/4885CYP2D6 193/4885CYP2C9 177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.