Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 6/20 | 0.60 |
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.44 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.41 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5377580 | 0.81 | GSK3B (0.87) | GSK3BMAPTDYRK1ACDC7DBF4 | |
| SCHEMBL5381452 | 0.80 | GSK3B (0.65) | GSK3BIDO1CYP19A1CDC7DBF4 | |
| SCHEMBL5380569 | 0.79 | GSK3B (0.73) | GSK3BMAPTDYRK1ACDC7DBF4 | |
| SCHEMBL5375235 | 0.79 | IDO1 (0.49) | GSK3BIDO1MAPTCYP19A1DYRK1A | |
| SCHEMBL5381549 | 0.76 | GSK3B (1.00) | GSK3BMAPTPOLBCDC7DBF4 | |
| SCHEMBL5391583 | 0.75 | GSK3B (0.67) | GSK3BCDC7RAB9AMAPK13MAPK12 | |
| SCHEMBL5380875 | 0.75 | GSK3B (0.75) | GSK3BMAPTDYRK1ACDC7DBF4 | |
| SCHEMBL5400000 | 0.73 | GSK3B (0.73) | GSK3BMAPTCDC7MAPK13MAPK12 | |
| SCHEMBL5381426 | 0.73 | GSK3B (0.78) | GSK3BMAPTCYP19A1POLBCDC7 | |
| SCHEMBL5384096 | 0.73 | GSK3B (0.73) | GSK3BRAB9AMAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7256199-B1 | Pyrimidone derivatives | MITSUBISHI CHEMICAL CORPORATION (JP) | 2007-08-14 | — | — | US | disclosed |
| EP-1115721-B1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEM CORP (JP) | 2003-12-10 | — | — | EP | disclosed |