Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
| ▸ | CLK1 | P49759 | 1/20 | 0.46 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.44 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.38 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.38 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.38 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5377577 | 0.81 | CDC7 (0.49) | IDO1PKN1PKN2MAPTDYRK1A | |
| SCHEMBL5381446 | 0.80 | GSK3B (0.47) | IDO1MAPTMAPK13MAPK12MAPK11 | |
| SCHEMBL5375238 | 0.79 | GSK3B (0.60) | IDO1PKN1PKN2MAPTDYRK1A | |
| SCHEMBL5381545 | 0.76 | CDC7 (0.59) | IDO1PKN1PKN2MAPTMAPK13 | |
| SCHEMBL5391579 | 0.75 | MAPK14 (0.56) | MAPK13MAPK12MAPK11MAPK14NPC1 | |
| SCHEMBL5380873 | 0.73 | MAPK14 (0.49) | MAPTMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL5384093 | 0.73 | GCGR (0.56) | MAPK13MAPK12MAPK11MAPK14NPC1 | |
| SCHEMBL5399995 | 0.73 | MAPK14 (0.54) | MAPK13MAPK12MAPK11MAPK14GSK3B | |
| SCHEMBL7395689 | 0.73 | MAPK14 (0.48) | MAPTMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL5383550 | 0.73 | CDC7 (0.53) | MAPK14NPC1RAB9ANPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7256199-B1 | Pyrimidone derivatives | MITSUBISHI CHEMICAL CORPORATION (JP) | 2007-08-14 | — | — | US | disclosed |
| EP-1115721-B1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEM CORP (JP) | 2003-12-10 | — | — | EP | disclosed |