SCHEMBL5375288

SCHEMBL5375288

CN(C)C=C1C(=O)CCCN1C(c1ccccc1)(c1ccccc1)c1ccccc1

nearest known ligand 0.35

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAP1LC3B Q9GZQ8 2/20 0.35
SMARCA4 P51532 1/20 0.34
ALDH1A1 P00352 5/20 0.32
MAPT P10636 3/20 0.32
HTT P42858 2/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
HIF1A Q16665 1/20 0.32
CYP2B6 P20813 1/20 0.31
KDM4E B2RXH2 4/20 0.31
MEN1 O00255 2/20 0.31
KMT2A Q03164 2/20 0.31
GAA P10253 1/20 0.30
RECQL P46063 1/20 0.30
PBRM1 Q86U86 1/20 0.30
POLB P06746 1/20 0.30
PKM P14618 1/20 0.30
ALOX12 P18054 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9385567 0.72 SMARCA4 (0.34) MAP1LC3BSMARCA4ALDH1A1MAPTHTT
SCHEMBL9385565 0.72 SMARCA4 (0.34) MAP1LC3BSMARCA4ALDH1A1MAPTHTT
SCHEMBL8092347 0.72 HTT (0.41) ALDH1A1MAPTHTTSMN1; SMN2CYP2B6
SCHEMBL4399005 0.69 SMARCA4 (0.40) MAP1LC3BSMARCA4ALDH1A1MAPTHTT
SCHEMBL4399007 0.69 SMARCA4 (0.40) MAP1LC3BSMARCA4ALDH1A1MAPTHTT
SCHEMBL31230458 0.67 ALDH1A1 (0.45) ALDH1A1MAPTHTTSMN1; SMN2CYP2B6
SCHEMBL1528434 0.67 KDM4E (0.39) MAP1LC3BSMARCA4ALDH1A1MAPTHTT
SCHEMBL3479747 0.67 KDM4E (0.39) MAP1LC3BSMARCA4ALDH1A1MAPTHTT
SCHEMBL1528435 0.67 KDM4E (0.39) MAP1LC3BSMARCA4ALDH1A1MAPTHTT
SCHEMBL7921220 0.65 ITGB1 (0.37) ALDH1A1MAPTHTTCYP2B6MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1554256-A4 PIPERIDINO PYRIMIDINE DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OF DIABETES MERCK & CO INC (US) 2007-06-13 EP disclosed
EP-1554256-A1 PIPERIDINO PYRIMIDINE DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OF DIABETES Merck & Co., Inc. (US) 2005-07-20 EP disclosed
WO-2004007468-A1 PIPERIDINO PYRIMIDINE DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OF DIABETES MERCK & CO., INC. (US) 2004-01-22 WO disclosed