Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31230458 | 0.94 | ALDH1A1 (0.45) | HTTALDH1A1L3MBTL1MAPTHSD17B10 | |
| SCHEMBL7921220 | 0.88 | ITGB1 (0.37) | HTTALDH1A1L3MBTL1MAPTHSD17B10 | |
| SCHEMBL4110409 | 0.82 | TSHR (0.37) | ALDH1A1L3MBTL1MAPTHSD17B10TSHR | |
| SCHEMBL2695770 | 0.81 | CYP2B6 (0.50) | HTTALDH1A1L3MBTL1MAPTHSD17B10 | |
| SCHEMBL18910024 | 0.79 | PER2 (0.42) | HTTALDH1A1TSHRSMN1; SMN2KDM4E | |
| SCHEMBL2697747 | 0.77 | CYP2B6 (0.53) | HTTALDH1A1L3MBTL1MAPTHSD17B10 | |
| SCHEMBL23424740 | 0.73 | LMNA (0.39) | HTTALDH1A1L3MBTL1MAPTHSD17B10 | |
| SCHEMBL5375288 | 0.72 | MAP1LC3B (0.35) | HTTALDH1A1MAPTHSD17B10SMN1; SMN2 | |
| SCHEMBL2490844 | 0.71 | PARL (0.41) | HTTALDH1A1TSHRSMN1; SMN2POLB | |
| SCHEMBL9136294 | 0.70 | CYP2B6 (0.42) | HTTALDH1A1L3MBTL1MAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1058682-A1 | HETEROCYCLIC DIARYLMETHYLENE DERIVATIVES, METHODS OF PREPARING THEM AND THEIR USES IN THERAPEUTICS | LABORATOIRES UPSA (FR) | 2000-12-13 | — | — | EP | disclosed |
| US-6004994-A | ANTIINFLAMMATORY AGENTS, CYCLOOXYGENASE INHIBITORS AND ANALGESICS | LABORATOIRES UPSA (FR) | 1999-12-21 | — | — | US | disclosed |
| WO-1999043664-A1 | HETEROCYCLIC DIARYLMETHYLENE DERIVATIVES, METHODS OF PREPARING THEM AND THEIR USES IN THERAPEUTICS | LABORATOIRES UPSA (FR) | 1999-09-02 | — | — | WO | disclosed |