SCHEMBL5375946

SCHEMBL5375946

C[Si](Cl)(Cl)c1ccccc1Cl

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.45
LMNA P02545 1/20 0.45
HPGD P15428 2/20 0.38
NPC1 O15118 1/20 0.38
TP53 P04637 1/20 0.38
RAB9A P51151 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
PNMT P11086 1/20 0.37
ALDH1A1 P00352 2/20 0.36
HSD11B1 P28845 1/20 0.35
CYP2A6 P11509 4/20 0.33
CYP1A2 P05177 3/20 0.33
NOTUM Q6P988 1/20 0.33
AHR P35869 1/20 0.33
POLB P06746 1/20 0.32
KMT2A Q03164 1/20 0.32
KCNH2 Q12809 1/20 0.32
CES2 O00748 1/20 0.32
CES1 P23141 1/20 0.32
IDO1 P14902 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1798315 0.84 TSHR (0.45) TSHRLMNAHPGDNPC1TP53
SCHEMBL16714013 0.83 TSHR (0.32) TSHRLMNAALDH1A1
SCHEMBL2565196 0.81 TSHR (0.47) TSHRLMNAHPGDNPC1TP53
SCHEMBL31193363 0.81 TSHR (0.47) TSHRLMNAHPGDNPC1TP53
SCHEMBL8372962 0.78 TSHR (0.50) TSHRLMNAHPGDNPC1TP53
SCHEMBL1225074 0.78 TSHR (0.50) TSHRLMNAHPGDNPC1TP53
SCHEMBL2098655 0.74 TSHR (0.45) TSHRHPGDNPC1RAB9ASMN1; SMN2
SCHEMBL17835353 0.73 TSHR (0.39) TSHRLMNAHPGDNPC1TP53
SCHEMBL29264599 0.73 TSHR (0.39) TSHRLMNAHPGDNPC1TP53
SCHEMBL17966549 0.72 CYP2A6 (0.56) TSHRLMNAHPGDNPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7211683-B2 Process for preparing organosilanes WACKER CHEMIE AG (DE) 2007-05-01 US disclosed
US-7169873-B2 Silsesquioxane derivatives and process for production thereof CHISSO CORPORATION (JP) 2007-01-30 US disclosed
US-20050137413-A1 Process for preparing organosilanes WACKER-CHEMIE GMBH (DE) 2005-06-23 US disclosed
US-6885024-B2 Devices with organic crystallite active channels LUCENT TECHNOLOGIES INC. (US) 2005-04-26 US disclosed
US-20040061104-A1 Devices with organic crystallite active channels RPX CORPORATION 2004-04-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050137413-A1 Process for preparing organosilanes C1S, HRH3, RTN3 TSHR 1723/4885LMNA 2602/4885HPGD 1146/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.