Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP2 | Q9UGN5 | 6/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.44 |
| ▸ | OGFRL1 | Q5TC84 | 6/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 10/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.39 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4654650 | 0.98 | PARP2 (0.43) | PARP2OPRM1OGFRL1OPRK1OPRD1 | |
| SCHEMBL4655667 | 0.95 | PARP2 (0.41) | PARP2OPRM1OGFRL1OPRK1OPRD1 | |
| SCHEMBL5381512 | 0.93 | PARP2 (0.46) | PARP2OPRM1OGFRL1OPRK1OPRD1 | |
| SCHEMBL5376556 | 0.91 | PARP2 (0.44) | PARP2OPRM1OGFRL1OPRK1OPRD1 | |
| SCHEMBL5386046 | 0.89 | ALDH1A1 (0.41) | PARP2OPRM1OGFRL1OPRK1OPRD1 | |
| SCHEMBL5371518 | 0.87 | PARP1 (0.46) | PARP2OPRM1OGFRL1OPRK1OPRD1 | |
| SCHEMBL33525767 | 0.84 | NOS3 (0.36) | OPRM1OGFRL1OPRK1OPRD1PARP1 | |
| SCHEMBL4656934 | 0.82 | PARP2 (0.42) | PARP2PARP1 | |
| SCHEMBL5376108 | 0.79 | PARP1 (0.43) | PARP1 | |
| SCHEMBL5390708 | 0.79 | PARP2 (0.34) | PARP2OPRM1OGFRL1OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7169795-B2 | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors | BRISTOL MYERS SQUIBB COMPANY (US) | 2007-01-30 | — | — | US | claimed |
| US-20050096309-A1 | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2005-05-05 | — | — | US | claimed |
| US-7312218-B2 | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors | BRISTOL MYERS SQUIBB CO. (US) | 2007-12-25 | — | — | US | disclosed |
| US-20070099922-A1 | SULFONYLAMINOVALEROLACTAMS AND DERIVATIVES THEREOF AS FACTOR XA INHIBITORS | HAN WEI | 2007-05-03 | — | — | US | disclosed |
| US-7169795-B2 | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors | BRISTOL MYERS SQUIBB COMPANY (US) | 2007-01-30 | — | — | US | disclosed |
| US-20050096309-A1 | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2005-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099922-A1 | SULFONYLAMINOVALEROLACTAMS AND DERIVATIVES THEREOF AS FACTOR XA INHIBITORS | TFPI, F12, F5 | PARP2 3321/4885OPRM1 4572/4885OGFRL1 922/4885 |
| US-20050096309-A1 | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors | TFPI, F12, F5 | PARP2 3321/4885OPRM1 4572/4885OGFRL1 922/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.