SCHEMBL5376445

SCHEMBL5376445

CCOc1nn(Cc2ccc(OC(c3ccccn3)c3c[nH]nc3C)cc2)cc1CCC(=O)O

nearest known ligand 0.34

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PPARG P37231 3/20 0.34
PPARD Q03181 3/20 0.34
PPARA Q07869 3/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
PLA2G4A P47712 1/20 0.34
FFAR4 Q5NUL3 5/20 0.33
CYP2C9 P11712 1/20 0.33
GAA P10253 2/20 0.33
KMO O15229 1/20 0.33
FFAR1 O14842 2/20 0.33
CACNA1G O43497 1/20 0.33
CACNA1H O95180 1/20 0.33
CACNA1I Q9P0X4 1/20 0.33
LMNA P02545 1/20 0.32
PTGDR2 Q9Y5Y4 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5385713 0.93 CYP4F2 (0.34) GAACACNA1GCACNA1HCACNA1ILMNA
SCHEMBL5382751 0.85 HDAC1 (0.38) FFAR4GAACACNA1GCACNA1HCACNA1I
SCHEMBL6034579 0.83 FFAR1 (0.46) L3MBTL1FFAR4FFAR1LMNA
SCHEMBL6035227 0.78 LMNA (0.36) PPARDCYP2C9GAALMNAPTGDR2
SCHEMBL5380398 0.76 PPARG (0.34) PPARGPPARACYP2C9GAALMNA
SCHEMBL5373798 0.75 FFAR1 (0.54) PLA2G4AFFAR4FFAR1CACNA1GCACNA1H
SCHEMBL5376441 0.75 FFAR4 (0.42) L3MBTL1FFAR4CYP2C9FFAR1PTGDR2
SCHEMBL5385639 0.74 FFAR1 (0.47) PPARGPPARAL3MBTL1FFAR4CYP2C9
SCHEMBL5385675 0.72 FFAR1 (0.40) PLA2G4ACYP2C9GAAFFAR1LMNA
SCHEMBL5377419 0.71 P2RX3 (0.44) FFAR4CYP2C9FFAR1CACNA1GCACNA1H

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7179823-B1 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-02-20 US claimed
EP-1457490-A1 5-membered N-heterocyclic compounds with hypoglycemic and hypolipidemic activity Takeda Chemical Industries, Ltd. (JP) 2004-09-15 EP claimed
EP-1228067-B1 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2004-07-14 EP claimed
EP-1228067-A1 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGYLCEMIC AND HYPOLIPIDEMIC ACTIVITY Takeda Chemical Industries, Ltd. (JP) 2002-08-07 EP claimed
WO-2001038325-A1 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-05-31 WO claimed
US-7179823-B1 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-02-20 US disclosed
EP-1457490-A1 5-membered N-heterocyclic compounds with hypoglycemic and hypolipidemic activity Takeda Chemical Industries, Ltd. (JP) 2004-09-15 EP disclosed
EP-1228067-B1 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2004-07-14 EP disclosed
EP-1228067-A1 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGYLCEMIC AND HYPOLIPIDEMIC ACTIVITY Takeda Chemical Industries, Ltd. (JP) 2002-08-07 EP disclosed
WO-2001038325-A1 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-05-31 WO disclosed