SCHEMBL5376895

SCHEMBL5376895

CCOC(=O)CCc1cn(Cc2cccc(C(=O)Nc3ccccn3)c2)nc1-c1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 2/20 0.44
HDAC7 Q8WUI4 1/20 0.44
ALDH1A1 P00352 3/20 0.42
SMN1; SMN2 Q16637 3/20 0.42
KDM4E B2RXH2 1/20 0.42
HDAC6 Q9UBN7 1/20 0.41
SIRT2 Q8IXJ6 1/20 0.41
PTGER1 P34995 1/20 0.41
NPC1 O15118 2/20 0.39
RAB9A P51151 2/20 0.39
KMT2A Q03164 2/20 0.39
MEN1 O00255 1/20 0.39
GAA P10253 1/20 0.39
NFKB1 P19838 1/20 0.39
NFKB2 Q00653 1/20 0.39
RELA Q04206 1/20 0.39
LMNA P02545 2/20 0.39
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2C9 P11712 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5381935 0.89 HDAC1 (0.48) HDAC1HDAC7ALDH1A1SMN1; SMN2KDM4E
SCHEMBL5381911 0.87 NAMPT (0.45) HDAC1HDAC7ALDH1A1SMN1; SMN2KDM4E
SCHEMBL5387764 0.87 NAMPT (0.42) HDAC1HDAC7ALDH1A1HDAC6NPC1
SCHEMBL5376980 0.86 ALDH1A1 (0.44) HDAC1HDAC7ALDH1A1KDM4ESIRT2
SCHEMBL5371997 0.85 HDAC1 (0.49) HDAC1HDAC7ALDH1A1SMN1; SMN2KDM4E
SCHEMBL5377209 0.80 EPHX2 (0.47) HDAC1HDAC7MAPK14
SCHEMBL5381180 0.77 HDAC1 (0.52) HDAC1HDAC7ALDH1A1SMN1; SMN2KDM4E
SCHEMBL5383041 0.77 HDAC1 (0.53) HDAC1HDAC7ALDH1A1SMN1; SMN2KDM4E
SCHEMBL5392241 0.76 NAMPT (0.50) HDAC1HDAC7ALDH1A1SMN1; SMN2KDM4E
SCHEMBL5385336 0.75 HDAC1 (0.46) HDAC1HDAC7ALDH1A1HDAC6NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7179823-B1 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-02-20 US disclosed
EP-1457490-A1 5-membered N-heterocyclic compounds with hypoglycemic and hypolipidemic activity Takeda Chemical Industries, Ltd. (JP) 2004-09-15 EP disclosed
EP-1228067-B1 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2004-07-14 EP disclosed
EP-1228067-A1 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGYLCEMIC AND HYPOLIPIDEMIC ACTIVITY Takeda Chemical Industries, Ltd. (JP) 2002-08-07 EP disclosed
WO-2001038325-A1 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-05-31 WO disclosed