SCHEMBL5376980

SCHEMBL5376980

CCOC(=O)CCc1cn(Cc2cccc(C(=O)Nc3cccnc3)c2)nc1-c1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.44
GAA P10253 2/20 0.44
MAPT P10636 2/20 0.44
KDM4E B2RXH2 1/20 0.44
TSHR P16473 2/20 0.43
MAPK1 P28482 2/20 0.43
HDAC1 Q13547 1/20 0.43
HDAC7 Q8WUI4 1/20 0.43
SIRT2 Q8IXJ6 1/20 0.42
NAMPT P43490 4/20 0.42
NPC1 O15118 2/20 0.41
LMNA P02545 1/20 0.41
RAB9A P51151 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
TRPV1 Q8NER1 1/20 0.41
IRAK1 P51617 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5393589 0.89 ALDH1A1 (0.48) ALDH1A1GAAMAPTKDM4EHDAC1
SCHEMBL5376895 0.86 HDAC1 (0.44) ALDH1A1GAAKDM4EHDAC1HDAC7
SCHEMBL5371997 0.84 HDAC1 (0.49) ALDH1A1GAAMAPTKDM4ETSHR
SCHEMBL5381911 0.81 NAMPT (0.45) ALDH1A1GAAMAPTKDM4EHDAC1
SCHEMBL5387764 0.81 NAMPT (0.42) ALDH1A1GAAHDAC1HDAC7NAMPT
SCHEMBL5377209 0.79 EPHX2 (0.47) HDAC1HDAC7
SCHEMBL5381180 0.76 HDAC1 (0.52) ALDH1A1GAAMAPTKDM4ETSHR
SCHEMBL5383041 0.76 HDAC1 (0.53) ALDH1A1GAAMAPTKDM4EHDAC1
SCHEMBL5381935 0.74 HDAC1 (0.48) ALDH1A1GAAMAPTKDM4ETSHR
SCHEMBL5380613 0.74 ALDH1A1 (0.54) ALDH1A1GAAMAPTKDM4EHDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7179823-B1 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-02-20 US disclosed
EP-1457490-A1 5-membered N-heterocyclic compounds with hypoglycemic and hypolipidemic activity Takeda Chemical Industries, Ltd. (JP) 2004-09-15 EP disclosed
EP-1228067-B1 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2004-07-14 EP disclosed
EP-1228067-A1 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGYLCEMIC AND HYPOLIPIDEMIC ACTIVITY Takeda Chemical Industries, Ltd. (JP) 2002-08-07 EP disclosed
WO-2001038325-A1 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-05-31 WO disclosed