Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CCNC | P24863 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6593864 | 0.87 | SMN1; SMN2 (0.48) | NPC1RAB9AMAPK14SMN1; SMN2HPGD | |
| SCHEMBL6593855 | 0.87 | SMN1; SMN2 (0.48) | NPC1RAB9AMAPK14SMN1; SMN2HPGD | |
| SCHEMBL5377216 | 0.83 | CYP19A1 (0.51) | NPC1RAB9ASMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL28757208 | 0.79 | CCNC (0.45) | NPC1RAB9ASMN1; SMN2HPGDCCNC | |
| SCHEMBL28757209 | 0.79 | CCNC (0.45) | NPC1RAB9ASMN1; SMN2HPGDCCNC | |
| SCHEMBL5377123 | 0.78 | TSHR (0.43) | NPC1RAB9AMAPK14SMN1; SMN2HPGD | |
| SCHEMBL5382860 | 0.78 | SMN1; SMN2 (0.58) | NPC1MAPK14SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL5377010 | 0.76 | MAPK14 (0.42) | NPC1RAB9AMAPK14SMN1; SMN2HPGD | |
| SCHEMBL23400358 | 0.71 | TSHR (0.46) | MAPK14SMN1; SMN2HPGDALDH1A1KMT2A | |
| SCHEMBL5377143 | 0.70 | MEN1 (0.49) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7179823-B1 | 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-20 | — | — | US | disclosed |