Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | CCNC | P24863 | 2/20 | 0.46 |
| ▸ | CDK8 | P49336 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28757209 | 0.93 | CCNC (0.45) | CYP19A1NPC1RAB9ACCNCCDK8 | |
| SCHEMBL28757208 | 0.93 | CCNC (0.45) | CYP19A1NPC1RAB9ACCNCCDK8 | |
| SCHEMBL6596244 | 0.84 | GAA (0.57) | CYP19A1NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL6596242 | 0.84 | GAA (0.57) | CYP19A1NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL5377004 | 0.83 | NPC1 (0.47) | CYP19A1NPC1RAB9ACCNCCDK8 | |
| SCHEMBL3491679 | 0.77 | ALDH1A1 (0.65) | CYP19A1NPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL4833608 | 0.77 | GAA (0.49) | NPC1RAB9ASMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL4833619 | 0.77 | GAA (0.49) | NPC1RAB9ASMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL7539976 | 0.75 | CYP19A1 (0.54) | CYP19A1SMN1; SMN2POLBALDH1A1MAPK1 | |
| SCHEMBL5377221 | 0.75 | CYP19A1 (0.43) | CYP19A1NPC1RAB9ASMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7179823-B1 | 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-20 | — | — | US | disclosed |