Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGER | Q15109 | 7/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.36 |
| ▸ | FDPS | P14324 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14283223 | 0.77 | SMN1; SMN2 (0.40) | MAPTLMNACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL306478 | 0.76 | PTGS2 (0.46) | LMNACYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL309078 | 0.76 | DPP4 (0.41) | MAPTLMNAAPAF1THRBPOLB | |
| SCHEMBL12894983 | 0.70 | DHODH (0.43) | AGERMEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL13387199 | 0.68 | LMNA (0.42) | AGERMAPTLMNAMEN1KMT2A | |
| SCHEMBL12894985 | 0.67 | NR4A2 (0.46) | LMNAMEN1KMT2AMAPK1TSHR | |
| SCHEMBL2690995 | 0.66 | TRPV1 (0.69) | MEN1KMT2ACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL16333135 | 0.65 | PIK3CD (0.37) | MAPTLMNAMEN1KMT2ATP53 | |
| SCHEMBL4973246 | 0.65 | SMN1; SMN2 (0.66) | MAPTLMNAMEN1KMT2ATP53 | |
| SCHEMBL4973402 | 0.65 | TP53 (0.50) | MAPTLMNAMEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797067-A1 | NEW HETEROCYCLIC AMIDES | AstraZeneca AB (SE) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006033620-A1 | NEW HETEROCYCLIC AMIDES | ASTRAZENECA AB (SE) | 2006-03-30 | — | — | WO | disclosed |