Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 16/20 | 0.50 |
| ▸ | FFAR4 | Q5NUL3 | 6/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.46 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5397024 | 0.90 | HDAC1 (0.43) | FFAR1FFAR4AKR1B1HDAC1HDAC7 | |
| SCHEMBL5377099 | 0.88 | FFAR1 (0.56) | FFAR1FFAR4AKR1B1HDAC1HDAC7 | |
| SCHEMBL5387558 | 0.88 | ALDH1A1 (0.51) | FFAR1FFAR4AKR1B1HDAC1HDAC7 | |
| SCHEMBL5372527 | 0.88 | FFAR1 (0.47) | FFAR1FFAR4AKR1B1PTGER4PTGER3 | |
| SCHEMBL5383105 | 0.85 | HDAC1 (0.48) | FFAR1FFAR4AKR1B1HDAC1HDAC7 | |
| SCHEMBL5380982 | 0.84 | GAA (0.50) | FFAR1FFAR4AKR1B1HDAC1HDAC7 | |
| SCHEMBL5385908 | 0.80 | FFAR1 (0.49) | FFAR1FFAR4AKR1B1HDAC1HDAC7 | |
| SCHEMBL5385561 | 0.80 | FFAR1 (0.40) | FFAR1FFAR4AKR1B1HDAC1MAPT | |
| SCHEMBL5393783 | 0.80 | FFAR1 (0.66) | FFAR1AKR1B1 | |
| SCHEMBL5384888 | 0.79 | HDAC1 (0.55) | FFAR1FFAR4HDAC1HDAC7GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7179823-B1 | 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-20 | — | — | US | disclosed |
| EP-1457490-A1 | 5-membered N-heterocyclic compounds with hypoglycemic and hypolipidemic activity | Takeda Chemical Industries, Ltd. (JP) | 2004-09-15 | — | — | EP | disclosed |
| EP-1228067-B1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-07-14 | — | — | EP | disclosed |
| EP-1228067-A1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGYLCEMIC AND HYPOLIPIDEMIC ACTIVITY | Takeda Chemical Industries, Ltd. (JP) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001038325-A1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-31 | — | — | WO | disclosed |