Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 11/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 6/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.44 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.42 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.42 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5385908 | 0.96 | FFAR1 (0.49) | GAAFFAR1HDAC1HDAC7AKR1B1 | |
| SCHEMBL5374912 | 0.89 | HDAC1 (0.44) | GAAFFAR1HDAC1HDAC7CYP19A1 | |
| SCHEMBL5380635 | 0.87 | FFAR1 (0.46) | GAAFFAR1AKR1B1CYP19A1FFAR4 | |
| SCHEMBL5377099 | 0.87 | FFAR1 (0.56) | GAAFFAR1HDAC1HDAC7AKR1B1 | |
| SCHEMBL5393783 | 0.86 | FFAR1 (0.66) | FFAR1AKR1B1CYSLTR2CYSLTR1 | |
| SCHEMBL5397393 | 0.86 | HDAC1 (0.41) | GAAFFAR1HDAC1HDAC7CYP19A1 | |
| SCHEMBL5377315 | 0.84 | FFAR1 (0.50) | GAAFFAR1HDAC1HDAC7AKR1B1 | |
| SCHEMBL5383105 | 0.84 | HDAC1 (0.48) | GAAFFAR1HDAC1HDAC7AKR1B1 | |
| SCHEMBL5381554 | 0.83 | HDAC1 (0.46) | GAAFFAR1HDAC1HDAC7AKR1B1 | |
| SCHEMBL5387558 | 0.83 | ALDH1A1 (0.51) | GAAFFAR1HDAC1HDAC7AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7179823-B1 | 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-20 | — | — | US | disclosed |
| EP-1457490-A1 | 5-membered N-heterocyclic compounds with hypoglycemic and hypolipidemic activity | Takeda Chemical Industries, Ltd. (JP) | 2004-09-15 | — | — | EP | disclosed |
| EP-1228067-B1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-07-14 | — | — | EP | disclosed |
| EP-1228067-A1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGYLCEMIC AND HYPOLIPIDEMIC ACTIVITY | Takeda Chemical Industries, Ltd. (JP) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001038325-A1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-31 | — | — | WO | disclosed |