SCHEMBL5377404

SCHEMBL5377404

CCCCCCc1cc(Oc2ccc(N)c(CCCCCC)c2)ccc1N

nearest known ligand 0.44

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
NR4A1 P22736 1/20 0.44
TSHR P16473 3/20 0.41
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
ALOX5 P09917 2/20 0.41
TP53 P04637 1/20 0.41
CYP3A4 P08684 1/20 0.41
MAPT P10636 1/20 0.41
TYR P14679 1/20 0.41
ALOX15 P16050 1/20 0.41
HTT P42858 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
ALDH1A1 P00352 1/20 0.40
TLR8 Q9NR97 1/20 0.40
HTR2A P28223 2/20 0.39
LIPG Q9Y5X9 1/20 0.39
LTA4H P09960 1/20 0.39
SKP2 Q13309 1/20 0.39
CNR2 P34972 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5382655 0.98 NR4A1 (0.45) NR4A1TSHRMEN1KMT2AALOX5
SCHEMBL3125693 0.94 ALDH1A1 (0.43) NR4A1TSHRMEN1KMT2ACYP3A4
SCHEMBL31457292 0.94 ALDH1A1 (0.43) NR4A1TSHRMEN1KMT2ACYP3A4
SCHEMBL5382666 0.93 NR4A1 (0.47) NR4A1TSHRMEN1KMT2AMAPT
SCHEMBL31457298 0.92 ALDH1A1 (0.44) NR4A1TSHRMEN1KMT2ACYP3A4
SCHEMBL7771779 0.88 HTR2A (0.45) MEN1KMT2AALOX5CYP3A4TDP1
SCHEMBL28191466 0.87 MEN1 (0.50) TSHRMEN1KMT2ATP53CYP3A4
SCHEMBL26632614 0.87 TSHR (0.55) TSHRMEN1KMT2ATP53CYP3A4
SCHEMBL31457326 0.87 ALDH1A1 (0.46) NR4A1TSHRMEN1KMT2ACYP3A4
SCHEMBL5377423 0.85 NR4A1 (0.50) NR4A1TSHRMEN1KMT2ACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-100475912-C Halogen-free resin composition CHANG CHUN PLASTICS CO LTD (CN) 2009-04-08 CN disclosed
CN-1333014-C Halogen-free resin composition CHANGCHU ARTIFICIAL RESIN FACT (CN) 2007-08-22 CN disclosed
US-7202359-B2 Azaoxa heterocyclic compound and method of preparing the same CHANG CHUN PLASTICS CO., LTD. (TW) 2007-04-10 US disclosed
US-7084194-B2 Halogen-free resin composition CHANG CHUN PLASTICS CO., LTD. (TW) 2006-08-01 US disclosed
CN-1234706-C Nitrogen-oxygen heterocyclic compound and preparation method thereof CHANGCHUN ARTIFICIAL RESIN FAC (CN) 2006-01-04 CN disclosed
US-6900269-B2 Halogen-free resin composition CHANG CHUN PLASTICS CO., LTD. (TW) 2005-05-31 US disclosed
US-20050085634-A1 Azaoxa heterocyclic compound and method of preparing the same CHANG CHUN PLASTICS CO., LTD. (TW) 2005-04-21 US disclosed
CN-1580127-A Halogen-free resin composition CHANGCHU ARTIFICIAL RESIN FACT (CN) 2005-02-16 CN disclosed
CN-1580128-A Halogen-free resin composition CHANGCHUN ARTIFICIAL RESIN FAC (CN) 2005-02-16 CN disclosed
US-20040158023-A1 Halogen-free resin composition CHANG CHUN PLASTICS CO., LTD. (TW) 2004-08-12 US disclosed
US-20040147640-A1 Halogen-free resin composition CHANG CHUN PLASTICS CO., LTD. (TW) 2004-07-29 US disclosed
CN-1490318-A Nitrogen-oxygen heterocyclic compound and preparation method thereof 长春人造树脂厂股份有限公司 2004-04-21 CN disclosed
US-20040068084-A1 Azaoxa heterocyclic compound and method of preparing the same CHANG CHUN PLASTICS CO., LTD. (TW) 2004-04-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040068084-A1 Azaoxa heterocyclic compound and method of preparing the same AOX1, KDM1A, BMI1 NR4A1 1060/4885TSHR 4548/4885MEN1 3378/4885
US-20050085634-A1 Azaoxa heterocyclic compound and method of preparing the same AOX1, KDM1A, BMI1 NR4A1 1141/4885TSHR 4491/4885MEN1 3668/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.