Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.72 |
| ▸ | RAB9A | P51151 | 7/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.72 |
| ▸ | MITF | O75030 | 1/20 | 0.72 |
| ▸ | PKM | P14618 | 1/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5380567 | 0.87 | RAB9A (0.77) | NPC1RAB9AKMT2AMITFPKM | |
| SCHEMBL5385662 | 0.83 | NPC1 (0.73) | NPC1RAB9AKMT2AMITFPKM | |
| SCHEMBL5462927 | 0.82 | NPC1 (0.72) | NPC1RAB9AKMT2AMITFPKM | |
| SCHEMBL5384920 | 0.76 | NPC1 (0.79) | NPC1RAB9AKMT2AMITFPKM | |
| SCHEMBL7078522 | 0.76 | NPC1 (0.69) | NPC1RAB9AKMT2AMITFPKM | |
| SCHEMBL7078524 | 0.76 | NPC1 (0.69) | NPC1RAB9AKMT2AMITFPKM | |
| SCHEMBL5454302 | 0.75 | NPC1 (0.77) | NPC1RAB9AKMT2AMITFPKM | |
| SCHEMBL6418277 | 0.74 | LMNA (0.71) | NPC1RAB9AKMT2ASMN1; SMN2HPGD | |
| SCHEMBL7457308 | 0.72 | NPC1 (0.64) | NPC1RAB9AKMT2AMITFPKM | |
| SCHEMBL7467062 | 0.72 | NPC1 (0.64) | NPC1RAB9AKMT2AMITFPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7179823-B1 | 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-20 | — | — | US | disclosed |
| EP-1457490-A1 | 5-membered N-heterocyclic compounds with hypoglycemic and hypolipidemic activity | Takeda Chemical Industries, Ltd. (JP) | 2004-09-15 | — | — | EP | disclosed |
| EP-1228067-B1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-07-14 | — | — | EP | disclosed |