Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | KCNN2 | Q9H2S1 | 4/20 | 0.41 |
| ▸ | KCNN3 | Q9UGI6 | 4/20 | 0.41 |
| ▸ | KCNN1 | Q92952 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3143094 | 1.00 | NQO2 (0.43) | NQO2MTNR1AMTNR1BABCB1KCNN2 | |
| SCHEMBL3162728 | 1.00 | NQO2 (0.43) | NQO2MTNR1AMTNR1BABCB1KCNN2 | |
| Hydrochloric Acid SCHEMBL9427134 | 0.98 | KCNN2 (0.42) | NQO2MTNR1AMTNR1BABCB1KCNN2 | |
| SCHEMBL4244596 | 0.90 | ABCB1 (0.42) | NQO2MTNR1AMTNR1BABCB1KCNN2 | |
| SCHEMBL15158492 | 0.89 | NQO2 (0.43) | NQO2MTNR1AMTNR1BCYP3A4CHRM2 | |
| SCHEMBL4746611 | 0.89 | TAAR1 (0.42) | NQO2MTNR1AMTNR1BCHRM2HTR1A | |
| SCHEMBL4746590 | 0.89 | TAAR1 (0.42) | NQO2MTNR1AMTNR1BCHRM2HTR1A | |
| SCHEMBL31549 | 0.86 | CYP3A4 (0.43) | NQO2MTNR1AMTNR1BCYP3A4MAPT | |
| SCHEMBL383341 | 0.86 | CYP3A4 (0.43) | NQO2MTNR1AMTNR1BCYP3A4MAPT | |
| SCHEMBL7436614 | 0.86 | CYP3A4 (0.43) | NQO2MTNR1AMTNR1BCYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8927758-B2 | Process for the resolution of enantiomers of (3,4 dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)nitrile and application in the synthesis of ivabradine | LES LABORATORIES SERVIER (FR) | 2015-01-06 | — | — | US | disclosed |
| US-8778930-B2 | Process for the resolution of enantiomers of (3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)nitrile and application in the synthesis of ivabradine | LES LABORATORIES SERVIER (FR) | 2014-07-15 | — | — | US | disclosed |
| US-20130211070-A1 | NEW PROCESS FOR THE RESOLUTION OF ENANTIOMERS OF (3,4 DIMETHOXY-BICYCLO[4.2.0]OCTA-1,3,5-TRIEN-7-YL)NITRILE AND APPLICATION IN THE SYNTHESIS OF IVABRADINE | LES LABORATOIRES SERVIER (FR) | 2013-08-15 | — | — | US | disclosed |
| US-20130204032-A1 | NEW PROCESS FOR THE RESOLUTION OF ENANTIOMERS OF (3,4 DIMETHOXY-BICYCLO[4.2.0]OCTA-1,3,5-TRIEN-7-YL)NITRILE AND APPLICATION IN THE SYNTHESIS OF IVABRADINE | LES LABORATOIRES SERVIER (FR) | 2013-08-08 | — | — | US | disclosed |
| EP-2460797-A2 | Process for preparation of ivabradine hydrochloride | Cadila Healthcare Limited (IN) | 2012-06-06 | — | — | EP | disclosed |
| US-8119794-B2 | Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid | LES LABORATOIRES SERVIER (FR) | 2012-02-21 | — | — | US | disclosed |
| EP-2097383-B1 | Process for preparation of ivabradine hydrochloride | CADILA HEALTHCARE LTD (IN) | 2012-02-08 | — | — | EP | disclosed |
| US-8110701-B2 | Process for the preparation of functionalised benzocyclobutenes, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid | LES LABORATOIRES SERVIER (FR) | 2012-02-07 | — | — | US | disclosed |
| US-8101747-B2 | Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid | LES LABORATOIRES SERVIER (FR) | 2012-01-24 | — | — | US | disclosed |
| US-8097720-B2 | Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid | Les Laboratories Server (FR) | 2012-01-17 | — | — | US | disclosed |
| US-20100249398-A1 | Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid | LES LABORATOIRES SERVIER (FR) | 2010-09-30 | — | — | US | disclosed |
| US-20100160628-A1 | Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid | LES LABORATOIRES SERVIER (FR) | 2010-06-24 | — | — | US | disclosed |
| EP-2036892-B1 | 1,2,4,5-tetrahydro-3H-benzazepine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2010-03-10 | — | — | EP | disclosed |
| US-20100056778-A1 | Process for the resolution of enantiomers of (3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl) nitrile and application in the synthesis of ivabradine | LES LABORATOIRES SERVIER (FR) | 2010-03-04 | — | — | US | disclosed |
| US-20100016580-A1 | Process for the preparation of functionalised benzocyclobutenes, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid | LES LABORATOIRES SERVIER (FR) | 2010-01-21 | — | — | US | disclosed |
| EP-2097383-A2 | PROCESS FOR PREPARATION OF IVABRADINE HYDROCHLORIDE | Cadila Healthcare Limited (IN) | 2009-09-09 | — | — | EP | disclosed |
| WO-2009066041-A2 | DERIVATIVES OF 1,2,4,5-TETRAHYDRO-3H-BENZAZEPINES, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2009-05-28 | — | — | WO | disclosed |
| EP-2036892-A1 | 1,2,4,5-tetrahydro-3H-benzazepine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2009-03-18 | — | — | EP | disclosed |
| US-20090069296-A1 | 1,2,4,5-Tetrahydro-3H-benzazepine compounds, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2009-03-12 | — | — | US | disclosed |
| WO-2008065681-A2 | PROCESS FOR PREPARATION OF IVABRADINE HYDROCHLORIDE | CADILA HEALTHCARE LIMITED (IN) | 2008-06-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130211070-A1 | NEW PROCESS FOR THE RESOLUTION OF ENANTIOMERS OF (3,4 DIMETHOXY-BICYCLO[4.2.0]OCTA-1,3,5-TRIEN-7-YL)NITRILE AND APPLICATION IN THE SYNTHESIS OF IVABRADINE | HCN4, NISCH, SCN5A | NQO2 2169/4885MTNR1A 2118/4885MTNR1B 1871/4885 |
| US-20130204032-A1 | NEW PROCESS FOR THE RESOLUTION OF ENANTIOMERS OF (3,4 DIMETHOXY-BICYCLO[4.2.0]OCTA-1,3,5-TRIEN-7-YL)NITRILE AND APPLICATION IN THE SYNTHESIS OF IVABRADINE | HCN4, NISCH, SCN5A | NQO2 2169/4885MTNR1A 2118/4885MTNR1B 1871/4885 |
| US-20090069296-A1 | 1,2,4,5-Tetrahydro-3H-benzazepine compounds, a process for their preparation and pharmaceutical compositions containing them | OXER1, NR1H3, OXSR1 | NQO2 1600/4885MTNR1A 60/4885MTNR1B 65/4885 |
| US-20100249398-A1 | Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid | CYP4F2, CYP2F1, CYP2D6 | NQO2 553/4885MTNR1A 2929/4885MTNR1B 2008/4885 |
| US-20100016580-A1 | Process for the preparation of functionalised benzocyclobutenes, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid | BDKRB2, HRH2, C1R | NQO2 1170/4885MTNR1A 1951/4885MTNR1B 1781/4885 |
| US-20100056778-A1 | Process for the resolution of enantiomers of (3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl) nitrile and application in the synthesis of ivabradine | HCN4, NISCH, SCN5A | NQO2 1986/4885MTNR1A 1886/4885MTNR1B 1651/4885 |
| US-20100160628-A1 | Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid | CYP4F2, CYP2F1, CYP2D6 | NQO2 553/4885MTNR1A 2929/4885MTNR1B 2008/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.