Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.53 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.53 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 6/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5382667 | 0.81 | MAPT (0.55) | MAPTKDM4EALDH1A1HTTHSP90AA1 | |
| SCHEMBL5394144 | 0.71 | MAPT (0.52) | MAPTKDM4EALDH1A1HTTHSP90AA1 | |
| SCHEMBL5346560 | 0.69 | NR4A2 (0.59) | MAPTKDM4EALDH1A1TDP1KMT2A | |
| SCHEMBL5385573 | 0.69 | MAPT (0.50) | MAPTKDM4EALDH1A1HTTHSP90AA1 | |
| SCHEMBL5385493 | 0.68 | P4HB (0.61) | MAPTKDM4EALDH1A1HTTHSP90AA1 | |
| Hydrochloric Acid SCHEMBL6273768 | 0.68 | NR4A2 (0.57) | MAPTKDM4EALDH1A1TDP1KMT2A | |
| SCHEMBL12530584 | 0.65 | HSP90AA1 (0.76) | MAPTKDM4EALDH1A1HTTHSP90AA1 | |
| SCHEMBL27981623 | 0.64 | P4HB (0.58) | MAPTKDM4EALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL27981622 | 0.64 | P4HB (0.58) | MAPTKDM4EALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL15522619 | 0.64 | MAPT (0.45) | MAPTKDM4EALDH1A1HTTHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246790-B1 | SUBSTITUTED 1 AND 2 NAPHTHOL MANNICH BASES | GRUENENTHAL GMBH (DE) | 2005-05-04 | — | — | EP | claimed |
| US-6774136-B2 | Substituted 1 and 2 naphthol mannich bases | GRUENENTHAL GMBH (DE) | 2004-08-10 | — | — | US | claimed |
| US-20040147570-A1 | Substituted 1 and 2-naphthol mannich bases | GRUENENTHAL GMBH (DE) | 2004-07-29 | — | — | US | claimed |
| WO-2001047866-A9 | SUBSTITUTED 1 AND 2 NAPHTHOL MANNICH BASES | GRUENENTHAL GMBH (DE) | 2002-11-07 | — | — | WO | claimed |
| EP-1246790-A1 | SUBSTITUTED 1 AND 2 NAPHTHOL MANNICH BASES | Grünenthal GmbH (DE) | 2002-10-09 | — | — | EP | claimed |
| WO-2001047866-A1 | SUBSTITUTED 1 AND 2 NAPHTHOL MANNICH BASES | Grünenthal GmbH (DE) | 2001-07-05 | — | — | WO | claimed |
| US-7202242-B2 | Substituted 1 and 2-naphthol Mannich bases | GRUENENTHAL GMBH (DE) | 2007-04-10 | — | — | US | disclosed |
| US-7202242-B2 | Substituted 1 and 2-naphthol Mannich bases | GRUENENTHAL GMBH (DE) | 2007-04-10 | — | — | US | disclosed |
| US-7202242-B2 | Substituted 1 and 2-naphthol Mannich bases | GRUENENTHAL GMBH (DE) | 2007-04-10 | — | — | US | disclosed |
| EP-1246790-B1 | SUBSTITUTED 1 AND 2 NAPHTHOL MANNICH BASES | GRUENENTHAL GMBH (DE) | 2005-05-04 | — | — | EP | disclosed |
| US-6774136-B2 | Substituted 1 and 2 naphthol mannich bases | GRUENENTHAL GMBH (DE) | 2004-08-10 | — | — | US | disclosed |
| US-20040147570-A1 | Substituted 1 and 2-naphthol mannich bases | GRUENENTHAL GMBH (DE) | 2004-07-29 | — | — | US | disclosed |
| US-20040044061-A1 | Substituted 1 and 2 naphthol mannich bases | GRUENENTHAL GMBH (DE) | 2004-03-04 | — | — | US | disclosed |
| WO-2001047866-A9 | SUBSTITUTED 1 AND 2 NAPHTHOL MANNICH BASES | GRUENENTHAL GMBH (DE) | 2002-11-07 | — | — | WO | disclosed |
| EP-1246790-A1 | SUBSTITUTED 1 AND 2 NAPHTHOL MANNICH BASES | Grünenthal GmbH (DE) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001047866-A1 | SUBSTITUTED 1 AND 2 NAPHTHOL MANNICH BASES | Grünenthal GmbH (DE) | 2001-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040044061-A1 | Substituted 1 and 2 naphthol mannich bases | DPM1, ALG8, MAN2B1 | MAPT 1272/4885KDM4E 4537/4885ALDH1A1 1539/4885 |
| US-20040147570-A1 | Substituted 1 and 2-naphthol mannich bases | DPM1, ALG8, MAN2B1 | MAPT 1459/4885KDM4E 4560/4885ALDH1A1 1312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.