Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | HTT | P42858 | 5/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.55 |
| ▸ | PPP1CA | P62136 | 2/20 | 0.55 |
| ▸ | ALPL | P05186 | 1/20 | 0.55 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.52 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.52 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.52 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5394144 | 0.88 | MAPT (0.52) | MAPTKDM4EALDH1A1HTTTDP1 | |
| SCHEMBL5385573 | 0.86 | MAPT (0.50) | MAPTKDM4EALDH1A1HTTTDP1 | |
| SCHEMBL5378183 | 0.81 | MAPT (0.53) | MAPTKDM4EALDH1A1HTTTDP1 | |
| SCHEMBL5392885 | 0.76 | HSP90AA1 (0.46) | MAPTKDM4EALDH1A1HTTTDP1 | |
| SCHEMBL1239765 | 0.71 | KDM4E (1.00) | MAPTKDM4EALDH1A1HTTTDP1 | |
| SCHEMBL5383277 | 0.70 | P4HB (0.60) | MAPTKDM4EALDH1A1HTTPPP1CA | |
| SCHEMBL9253066 | 0.68 | KDM4E (0.49) | MAPTKDM4EALDH1A1HTTTDP1 | |
| SCHEMBL5387238 | 0.67 | MAPT (0.55) | MAPTKDM4EALDH1A1HTTTDP1 | |
| SCHEMBL5258234 | 0.67 | CNR1 (0.52) | MAPTOPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL9253403 | 0.66 | OPRL1 (0.54) | MAPTKDM4EALDH1A1HTTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246790-B1 | SUBSTITUTED 1 AND 2 NAPHTHOL MANNICH BASES | GRUENENTHAL GMBH (DE) | 2005-05-04 | — | — | EP | claimed |
| US-6774136-B2 | Substituted 1 and 2 naphthol mannich bases | GRUENENTHAL GMBH (DE) | 2004-08-10 | — | — | US | claimed |
| US-20040147570-A1 | Substituted 1 and 2-naphthol mannich bases | GRUENENTHAL GMBH (DE) | 2004-07-29 | — | — | US | claimed |
| WO-2001047866-A9 | SUBSTITUTED 1 AND 2 NAPHTHOL MANNICH BASES | GRUENENTHAL GMBH (DE) | 2002-11-07 | — | — | WO | claimed |
| EP-1246790-A1 | SUBSTITUTED 1 AND 2 NAPHTHOL MANNICH BASES | Grünenthal GmbH (DE) | 2002-10-09 | — | — | EP | claimed |
| WO-2001047866-A1 | SUBSTITUTED 1 AND 2 NAPHTHOL MANNICH BASES | Grünenthal GmbH (DE) | 2001-07-05 | — | — | WO | claimed |
| US-7202242-B2 | Substituted 1 and 2-naphthol Mannich bases | GRUENENTHAL GMBH (DE) | 2007-04-10 | — | — | US | disclosed |
| US-7202242-B2 | Substituted 1 and 2-naphthol Mannich bases | GRUENENTHAL GMBH (DE) | 2007-04-10 | — | — | US | disclosed |
| US-7202242-B2 | Substituted 1 and 2-naphthol Mannich bases | GRUENENTHAL GMBH (DE) | 2007-04-10 | — | — | US | disclosed |
| EP-1246790-B1 | SUBSTITUTED 1 AND 2 NAPHTHOL MANNICH BASES | GRUENENTHAL GMBH (DE) | 2005-05-04 | — | — | EP | disclosed |
| US-6774136-B2 | Substituted 1 and 2 naphthol mannich bases | GRUENENTHAL GMBH (DE) | 2004-08-10 | — | — | US | disclosed |
| US-20040147570-A1 | Substituted 1 and 2-naphthol mannich bases | GRUENENTHAL GMBH (DE) | 2004-07-29 | — | — | US | disclosed |
| US-20040044061-A1 | Substituted 1 and 2 naphthol mannich bases | GRUENENTHAL GMBH (DE) | 2004-03-04 | — | — | US | disclosed |
| WO-2001047866-A9 | SUBSTITUTED 1 AND 2 NAPHTHOL MANNICH BASES | GRUENENTHAL GMBH (DE) | 2002-11-07 | — | — | WO | disclosed |
| EP-1246790-A1 | SUBSTITUTED 1 AND 2 NAPHTHOL MANNICH BASES | Grünenthal GmbH (DE) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001047866-A1 | SUBSTITUTED 1 AND 2 NAPHTHOL MANNICH BASES | Grünenthal GmbH (DE) | 2001-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040044061-A1 | Substituted 1 and 2 naphthol mannich bases | DPM1, ALG8, MAN2B1 | MAPT 1272/4885KDM4E 4537/4885ALDH1A1 1539/4885 |
| US-20040147570-A1 | Substituted 1 and 2-naphthol mannich bases | DPM1, ALG8, MAN2B1 | MAPT 1459/4885KDM4E 4560/4885ALDH1A1 1312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.