Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 5/20 | 0.48 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 3/20 | 0.42 |
| ▸ | BCL9 | O00512 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14425365 | 1.00 | GRIN2B (0.48) | GRIN2BENPP2ACKR3NAMPTBCL9 | |
| SCHEMBL5360981 | 0.90 | ENPP2 (0.42) | GRIN2BENPP2HPGDALDH1A1KMT2A | |
| SCHEMBL14425370 | 0.90 | ENPP2 (0.42) | GRIN2BENPP2HPGDALDH1A1KMT2A | |
| SCHEMBL14425360 | 0.89 | GRIN2B (0.47) | GRIN2BENPP2NAMPTGAAHPGD | |
| SCHEMBL5365350 | 0.89 | GRIN2B (0.47) | GRIN2BENPP2NAMPTGAAHPGD | |
| SCHEMBL14425314 | 0.87 | F2 (0.48) | GRIN2BENPP2NAMPTCYP1A2GAA | |
| SCHEMBL5362085 | 0.87 | F2 (0.48) | GRIN2BENPP2NAMPTCYP1A2GAA | |
| SCHEMBL14425445 | 0.87 | F2 (0.48) | GRIN2BENPP2NAMPTCYP1A2GAA | |
| SCHEMBL5364450 | 0.85 | GRIN2B (0.48) | GRIN2BENPP2NAMPTCYP1A2GAA | |
| SCHEMBL14425359 | 0.85 | GRIN2B (0.48) | GRIN2BENPP2NAMPTCYP1A2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |