Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 1/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5378067 | 0.84 | SLC6A2 (0.45) | SLC6A2SLC6A4SMN1; SMN2ACHEMEN1 | |
| SCHEMBL5374870 | 0.82 | GAA (0.51) | ACHEGAA | |
| SCHEMBL5375990 | 0.80 | GAA (0.51) | TSHRACHEKMT2AGAA | |
| SCHEMBL5377672 | 0.79 | HDAC6 (0.49) | SLC6A2SLC6A4ACHEMAPTMEN1 | |
| SCHEMBL1064732 | 0.77 | F2 (0.56) | GRIN1GRIN2BSLC6A2SLC6A4SMN1; SMN2 | |
| SCHEMBL5371447 | 0.77 | HDAC6 (0.55) | SLC6A2SLC6A4ACHEGAA | |
| SCHEMBL5369137 | 0.77 | GAA (0.47) | SMN1; SMN2ACHEMAPTGAAGFER | |
| SCHEMBL31212419 | 0.76 | ACHE (0.67) | GRIN1GRIN2BSMN1; SMN2LMNATSHR | |
| SCHEMBL5377677 | 0.74 | GAA (0.50) | ACHEGAA | |
| SCHEMBL5374061 | 0.73 | GAA (0.45) | GRIN2BSLC6A2SLC6A4ACHEMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189739-B2 | Compounds and methods to treat cardiac failure and other disorders | SCIOS, INC. (US) | 2007-03-13 | — | — | US | claimed |
| EP-1080078-B1 | HETEROCYCLIC COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS | SCIOS INC (US) | 2006-02-01 | — | — | EP | claimed |