Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 3/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 4/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5371611 | 0.88 | HDAC6 (0.44) | GAAF2HDAC6HTR7GRIN2B | |
| SCHEMBL7220084 | 0.81 | HTR7 (0.46) | HDAC6HTR7SLC6A2SLC6A4MEN1 | |
| SCHEMBL5368021 | 0.81 | GAA (0.48) | GAAF2HDAC6GRIN2BTNKS | |
| SCHEMBL5371447 | 0.79 | HDAC6 (0.55) | GAAF2HDAC6TNKSPARP1 | |
| SCHEMBL5374870 | 0.78 | GAA (0.51) | GAAF2HDAC6TNKSPARP1 | |
| SCHEMBL5375990 | 0.78 | GAA (0.51) | GAAF2HDAC6TNKSPARP1 | |
| SCHEMBL5377677 | 0.77 | GAA (0.50) | GAAF2HDAC6TNKSPARP1 | |
| SCHEMBL5377672 | 0.76 | HDAC6 (0.49) | GAAF2HDAC6TNKSPARP1 | |
| SCHEMBL7073760 | 0.76 | SIGMAR1 (0.47) | GAAF2HDAC6HTR7ACHE | |
| SCHEMBL5369137 | 0.74 | GAA (0.47) | GAAF2HDAC6TNKSPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189739-B2 | Compounds and methods to treat cardiac failure and other disorders | SCIOS, INC. (US) | 2007-03-13 | — | — | US | disclosed |
| EP-1080078-B1 | HETEROCYCLIC COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS | SCIOS INC (US) | 2006-02-01 | — | — | EP | disclosed |
| US-6589954-B1 | Indoles, benzimidazoles and benztriazoles which are substituted at the 5 or 6 position with a substituent comprising an aromatic moiety linked through a piperazine ring to said indole, benzimidazole or benztriazole are useful | SCIOS, INC. | 2003-07-08 | — | — | US | disclosed |