Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 1/20 | 0.54 |
| ▸ | HTR6 | P50406 | 3/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | HTR1B | P28222 | 1/20 | 0.52 |
| ▸ | HTR7 | P34969 | 1/20 | 0.52 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 4/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | F10 | P00742 | 1/20 | 0.48 |
| ▸ | KHK | P50053 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16684845 | 0.79 | ULK1 (0.50) | ULK1ALOX15KHKKMT2AMEN1 | |
| SCHEMBL1105187 | 0.78 | ULK1 (0.55) | ULK1HTR6HTR1AHTR1BHTR7 | |
| SCHEMBL30440132 | 0.77 | NPC1 (0.62) | ULK1HTR6HTR1AHTR2BGSK3B | |
| SCHEMBL27023076 | 0.77 | NPC1 (0.62) | ULK1HTR6HTR1AHTR2BGSK3B | |
| SCHEMBL29851110 | 0.76 | P2RY14 (0.50) | GSK3BKHKKMT2AMEN1NPC1 | |
| SCHEMBL2467865 | 0.76 | ULK1 (0.56) | ULK1GSK3BALOX15F10KHK | |
| SCHEMBL23758889 | 0.76 | NPC1 (0.63) | GSK3BKMT2AMEN1CHRM5KDM4E | |
| SCHEMBL29542503 | 0.76 | DYRK1B (0.56) | ULK1GSK3BF10NPC1HPGD | |
| SCHEMBL8206181 | 0.76 | ULK1 (0.55) | ULK1HTR6HTR1AHTR1BHTR7 | |
| SCHEMBL1552756 | 0.75 | ULK1 (0.56) | ULK1ALOX15F10KHKHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414368-A2 | HYDROXYTHIENOQUINOLONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS | Achillion Pharmaceuticals, Inc. (US) | 2012-02-08 | — | — | EP | claimed |
| WO-2010115184-A2 | HYDROXYTHIENOQUINOLONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS | ACHILLION PHARMACEUTICALS, INC. (US) | 2010-10-07 | — | — | WO | claimed |