Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 13/20 | 0.43 |
| ▸ | SCN10A | Q9Y5Y9 | 4/20 | 0.43 |
| ▸ | CTSD | P07339 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5219279 | 0.78 | CTSD (0.51) | CTSDBACE1BACE2SIGMAR1 | |
| SCHEMBL5389542 | 0.76 | BACE1 (0.42) | SCN9ACTSDBACE1BACE2 | |
| SCHEMBL5221894 | 0.76 | BACE1 (0.49) | CTSDBACE1BACE2SIGMAR1 | |
| SCHEMBL18070777 | 0.74 | SCN9A (0.44) | SCN9ASCN10A | |
| SCHEMBL18070758 | 0.74 | SCN9A (0.44) | SCN9ASCN10A | |
| SCHEMBL18070765 | 0.74 | SCN9A (0.44) | SCN9ASCN10A | |
| SCHEMBL5383441 | 0.72 | CTSD (0.43) | SCN9ACTSDBACE1BACE2HTR6 | |
| SCHEMBL5387536 | 0.71 | CHRM2 (0.43) | SCN9A | |
| SCHEMBL18070784 | 0.71 | SCN9A (0.43) | SCN9ASCN10A | |
| SCHEMBL18070783 | 0.71 | SCN9A (0.43) | SCN9ASCN10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7253198-B2 | Hydroxyethylamine derivatives for the treatment of Alzheimer's disease | GLAXO GROUP LIMITED (GB) | 2007-08-07 | — | — | US | disclosed |
| US-20060025459-A1 | Hydroxyethylamine derivatives for the treatment of alzheimer's disease | GLAXO GROUP LIMITED (GB) | 2006-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060025459-A1 | Hydroxyethylamine derivatives for the treatment of alzheimer's disease | BACE2, PSEN2, BACE1 | SCN9A 2413/4885SCN10A 1352/4885CTSD 384/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.