Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 3/20 | 0.70 |
| ▸ | BCR | P11274 | 3/20 | 0.70 |
| ▸ | PRKCA | P17252 | 3/20 | 0.70 |
| ▸ | NPC1 | O15118 | 1/20 | 0.68 |
| ▸ | RAB9A | P51151 | 1/20 | 0.68 |
| ▸ | IKBKB | O14920 | 1/20 | 0.67 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.63 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.63 |
| ▸ | GSK3B | P49841 | 2/20 | 0.63 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.63 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.63 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.63 |
| ▸ | RHOA | P61586 | 1/20 | 0.62 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.61 |
| ▸ | AURKA | O14965 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | KDM6B | O15054 | 1/20 | 0.57 |
| ▸ | KDM4A | O75164 | 1/20 | 0.57 |
| ▸ | KDM5C | P41229 | 1/20 | 0.57 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4903688 | 0.89 | MAPK8 (0.63) | ABL1BCRPRKCAMAPK8PIK3CG | |
| SCHEMBL3123402 | 0.86 | ABL1 (0.74) | ABL1BCRPRKCAPRKD3PRKCG | |
| SCHEMBL5379812 | 0.84 | ABL1 (0.77) | ABL1BCRPRKCANPC1RAB9A | |
| SCHEMBL4902223 | 0.84 | ABL1 (0.80) | ABL1BCRPRKCANPC1RAB9A | |
| SCHEMBL7470857 | 0.83 | ABL1 (0.63) | ABL1BCRPRKCANPC1RAB9A | |
| SCHEMBL25339113 | 0.83 | ABL1 (0.65) | ABL1BCRPRKCANPC1RAB9A | |
| SCHEMBL31119021 | 0.83 | ABL1 (0.65) | ABL1BCRPRKCANPC1RAB9A | |
| SCHEMBL7470116 | 0.82 | JAK2 (0.68) | ABL1BCRPRKCAAURKAPRKD3 | |
| SCHEMBL1655099 | 0.82 | ABL1 (1.00) | ABL1BCRPRKCANPC1RAB9A | |
| SCHEMBL27115954 | 0.82 | ABL1 (0.74) | ABL1BCRPRKCANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |