Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 10/20 | 0.54 |
| ▸ | CDC7 | O00311 | 2/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.54 |
| ▸ | PIM1 | P11309 | 2/20 | 0.54 |
| ▸ | PRKACA | P17612 | 2/20 | 0.54 |
| ▸ | CDK2 | P24941 | 2/20 | 0.54 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.54 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.54 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | XBP1 | P17861 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14514019 | 0.87 | GSK3B (0.59) | GSK3BCDC7ROCK2MAP4K4PIM1 | |
| SCHEMBL5383599 | 0.83 | ADORA2A (0.62) | GSK3BCDC7ROCK2MAP4K4PIM1 | |
| SCHEMBL5380284 | 0.80 | GCGR (0.44) | CDC7MAPTSMN1; SMN2HTTTP53 | |
| SCHEMBL14514018 | 0.79 | CA1 (0.54) | GSK3BCDC7ROCK2MAP4K4PIM1 | |
| SCHEMBL3831637 | 0.76 | MAPT (0.61) | GSK3BCDC7ROCK2PIM1HIPK2 | |
| SCHEMBL5400018 | 0.75 | NCOA1 (0.63) | GSK3BCDC7ROCK2MAP4K4PIM1 | |
| SCHEMBL7992963 | 0.75 | GSK3B (0.79) | GSK3BCDC7ROCK2MAP4K4PIM1 | |
| SCHEMBL14514008 | 0.75 | BUB1 (0.49) | GSK3BCDC7ROCK2MAP4K4PIM1 | |
| SCHEMBL5380322 | 0.75 | PDE4B (0.58) | GSK3BCDC7ROCK2MAP4K4PIM1 | |
| SCHEMBL27642988 | 0.74 | GSK3B (0.57) | GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7256199-B1 | Pyrimidone derivatives | MITSUBISHI CHEMICAL CORPORATION (JP) | 2007-08-14 | — | — | US | claimed |
| US-7256199-B1 | Pyrimidone derivatives | MITSUBISHI CHEMICAL CORPORATION (JP) | 2007-08-14 | — | — | US | disclosed |