Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 4/20 | 0.58 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | MITF | O75030 | 1/20 | 0.51 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | BUB1 | O43683 | 1/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.48 |
| ▸ | GSK3B | P49841 | 3/20 | 0.48 |
| ▸ | GSK3A | P49840 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5383599 | 0.82 | ADORA2A (0.62) | ADORA2AMAPTKMT2ARAB9AMAPK1 | |
| SCHEMBL5400018 | 0.82 | NCOA1 (0.63) | ADORA2AMEN1KMT2ANPC1HTT | |
| SCHEMBL3830998 | 0.81 | MEN1 (0.54) | PDE4BMAPTMEN1KMT2AABCG2 | |
| SCHEMBL14514019 | 0.81 | GSK3B (0.59) | ADORA2AMAPTNPC1HTTMAPK1 | |
| SCHEMBL3825028 | 0.81 | XDH (0.51) | ADORA2AMAPTABCG2MAPK1KDM4E | |
| SCHEMBL14514001 | 0.80 | ADORA2A (0.54) | PDE4BADORA2AMAPTMEN1KMT2A | |
| SCHEMBL3832032 | 0.78 | ROCK2 (0.48) | ADORA2AMAPK1GSK3BGSK3ACDK5 | |
| SCHEMBL5391583 | 0.78 | GSK3B (0.67) | NPC1RAB9AGSK3BCDC7 | |
| SCHEMBL3831637 | 0.78 | MAPT (0.61) | ADORA2AMAPTMEN1KMT2ANPC1 | |
| SCHEMBL5380286 | 0.75 | GSK3B (0.54) | ADORA2AMAPTHTTMAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7256199-B1 | Pyrimidone derivatives | MITSUBISHI CHEMICAL CORPORATION (JP) | 2007-08-14 | — | — | US | claimed |
| US-7256199-B1 | Pyrimidone derivatives | MITSUBISHI CHEMICAL CORPORATION (JP) | 2007-08-14 | — | — | US | disclosed |
| US-20070117818-A1 | Pyrimidinone compounds useful as kinase inhibitors | HASEGAWA MASAICHI | 2007-05-24 | — | — | US | disclosed |
| US-20070117818-A1 | Pyrimidinone compounds useful as kinase inhibitors | HASEGAWA MASAICHI | 2007-05-24 | — | — | US | disclosed |
| EP-1115721-B1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEM CORP (JP) | 2003-12-10 | — | — | EP | disclosed |
| EP-1115721-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018758-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2000-04-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070117818-A1 | Pyrimidinone compounds useful as kinase inhibitors | HIPK3, HIPK1, HIPK2 | PDE4B 1705/4885ADORA2A 3908/4885MAPT 2835/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.