Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | AGPAT2 | O15120 | 10/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | PRNP | P04156 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.43 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5386005 | 0.81 | ALDH1A1 (0.57) | ALDH1A1KDM4EAGPAT2HPGDRECQL | |
| SCHEMBL27792666 | 0.80 | HSP90AA1 (0.58) | ALDH1A1HPGDMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2408309 | 0.79 | PTGER1 (0.61) | ALDH1A1KDM4EHPGDPPARGL3MBTL1 | |
| SCHEMBL5375905 | 0.77 | AGPAT2 (0.67) | ALDH1A1KDM4EAGPAT2RECQLMEN1 | |
| SCHEMBL3790136 | 0.76 | PDE4D (0.42) | HPGDCYP1A1CYP1A2CYP1B1KMT2A | |
| SCHEMBL7699644 | 0.75 | ALDH1A1 (0.56) | ALDH1A1KDM4EAGPAT2HPGDRECQL | |
| SCHEMBL4286846 | 0.75 | ALDH1A1 (0.55) | ALDH1A1KDM4EAGPAT2HPGDRECQL | |
| SCHEMBL1033197 | 0.75 | ALDH1A1 (0.55) | ALDH1A1KDM4EAGPAT2HPGDRECQL | |
| SCHEMBL28115232 | 0.75 | EGFR (0.40) | ALDH1A1CYP1A2MEN1KMT2AL3MBTL1 | |
| SCHEMBL16385306 | 0.74 | CYP1A2 (0.40) | ALDH1A1CYP1A1CYP1A2CYP1B1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070178134-A1 | Pyridines and uses thereof | CELL THERAPEUTICS, INC. (US) | 2007-08-02 | — | — | US | disclosed |
| US-7208507-B2 | Lysophosphatidic acid acyltransferase beta inhibitors; antiproliferative agents, treating tumors; [2-Chloro-6-(5-chloro-2-methoxy-phenyl)-pyridin-4-yl]-p-tolyl-amine for example | CELL THERAPEUTICS, INC. (US) | 2007-04-24 | — | — | US | disclosed |
| US-20050182102-A1 | Pyridines and uses thereof | CELL THERAPEUTICS, INC. (US) | 2005-08-18 | — | — | US | disclosed |
| US-6875781-B2 | Pyridines and uses thereof | CELL THERAPEUTICS, INC. (US) | 2005-04-05 | — | — | US | disclosed |
| US-20040198728-A1 | Pyridines and uses thereof | CELL THERAPEUTICS, INC. | 2004-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040198728-A1 | Pyridines and uses thereof | LPCAT3, LPCAT1, PLAAT2 | ALDH1A1 884/4885KDM4E 879/4885AGPAT2 23/4885 |
| US-20070178134-A1 | Pyridines and uses thereof | LPCAT3, LPCAT1, PLAAT2 | ALDH1A1 728/4885KDM4E 1025/4885AGPAT2 24/4885 |
| US-20050182102-A1 | Pyridines and uses thereof | LPCAT3, LPCAT1, PLAAT2 | ALDH1A1 728/4885KDM4E 1025/4885AGPAT2 24/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.